Evidence map›Paper›PMID 28222310›Full record

ArticlePsychiatry research2017

Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans.

Christiana G Martin, Hyungsuk Kim, Sijung Yun, Whitney Livingston, Joseph Fetta, Vincent Mysliwiec, Tristin Baxter, Jessica M Gill

Abstract read
In one paragraph

Article in Psychiatry research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
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  20. Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christiana G MartinNational Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: martinc2@nih.gov.
Hyungsuk KimNational Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Sijung YunYotta Biomed, Potomac, MD 20854, USA.
Whitney LivingstonNational Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Joseph FettaNational Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Vincent MysliwiecMadigan Army Medical Center, 9040A Fitzsimmons Avenue, Tacoma, WA 98431, USA.
Tristin BaxterMadigan Army Medical Center, 9040A Fitzsimmons Avenue, Tacoma, WA 98431, USA.
Jessica M GillNational Institutes of Nursing Research, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: gillj@mail.nih.gov.
National Institute of Nursing Research · USMadigan Army Medical Center · USNational Institutes of Health · US

Funding

Genomic Approaches for Elucidating Novel Targets for Pain and Symptom ManagementZIANR000015 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI KIM, HYUNG SUK · 2009 to 2021
$20.2M
Traumatic Brain Injury and Sleep Disorders in Military PersonnelZIANR000027 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI GILL, JESSICA · 2013 to 2021
$4.8M
Psychobiologic Resilience to TraumaZIANR000017 · NINR · NATIONAL INSTITUTE OF NURSING RESEARCH · PI GILL, JESSICA · 2009 to 2009
$11k
Intramural NIH HHS ZIA NR000017
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) affects many returning combat veterans, but underlying biological mechanisms remain unclear. In order to compare circulating micro RNA (miRNA) of combat veterans with and without PTSD, peripheral blood from 24 subjects was collected following deployment, and isolated miRNA was sequenced. PTSD was associated with 8 differentially expressed miRNA. Pathway analysis shows that PTSD is related to the axon guidance and Wnt signaling pathways, which work together to support neuronal development through regulation of growth cones. PTSD is associated with miRNAs that regulate biological functions including neuronal activities, suggesting that they play a role in PTSD symptomatology.

Indexed as

AdultAxon GuidanceCirculating MicroRNACohort StudiesCombat DisordersFemaleGenetic MarkersGrowth ConesHumansMaleRisk FactorsSequence Analysis, RNAStress Disorders, Post-TraumaticVeteransWnt Signaling PathwayCirculating MicroRNAGenetic MarkersBiomarkerMicro RNAPTSD

Identifiers

PMID28222310
PMCPMC6065100
OpenAlexW2580091278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.