Evidence map›Paper›PMID 28222301›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017

Impact of home visit capacity on genetic association studies of late-onset Alzheimer's disease.

David W Fardo, Laura E Gibbons, Shubhabrata Mukherjee, M Maria Glymour, Wayne McCormick, Susan M McCurry, James D Bowen, Eric B Larson, Paul K Crane

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Letter.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

David W FardoDepartment of Biostatistics and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
Laura E GibbonsDepartment of Medicine, University of Washington, Seattle, WA, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.
M Maria GlymourDepartment of Epidemiology, University of California, San Francisco, San Francisco, CA, USA.
Wayne McCormickDepartment of Medicine, University of Washington, Seattle, WA, USA.
Susan M McCurryDepartment of Psychosocial and Community Health, University of Washington, Seattle, WA, USA.
James D BowenDepartment of Neurology, Swedish Medical Center, Seattle, WA, USA.
Eric B LarsonGroup Health Research Institute, Group Health, Seattle, WA, USA.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, WA, USA. Electronic address: pcrane@uw.edu.
University of Washington · USGroup Health Cooperative · USSwedish Medical Center · USUniversity of Kentucky · USUniversity of San Francisco · US

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI BUCHWALD, DEDRA S · 1985 to 2019
$57.2M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Genetic architecture of memory and executive functioning in Alzheimer's diseaseR01AG042437 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K · 2014 to 2017
$2.7M
Statistical Genetics Methods for Mixed PathologiesK25AG043546 · NIA · UNIVERSITY OF KENTUCKY · PI FARDO, DAVID WILLIAM · 2013 to 2015
$445k
NIA NIH HHS K25 AG043546NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG042437NIA NIH HHS U01 AG006781
6 · The paper itself

Abstract

introductionFindings for genetic correlates of late-onset Alzheimer's disease (LOAD) in studies that rely solely on clinic visits may differ from those with capacity to follow participants unable to attend clinic visits.

methodsWe evaluated previously identified LOAD-risk single nucleotide variants in the prospective Adult Changes in Thought study, comparing hazard ratios (HRs) estimated using the full data set of both in-home and clinic visits (n = 1697) to HRs estimated using only data that were obtained from clinic visits (n = 1308). Models were adjusted for age, sex, principal components to account for ancestry, and additional health indicators.

resultsLOAD associations nominally differed for 4 of 21 variants; CR1 and APOE variants were significant after Bonferroni correction. DISCUSSION: Estimates of genetic associations may differ for studies limited to clinic-only designs. Home visit capacity should be explored as a possible source of heterogeneity and potential bias in genetic studies.

Indexed as

Genetic Association StudiesHouse CallsResearch DesignAgedAge FactorsAge of OnsetAlzheimer DiseaseApolipoproteins EFemaleFollow-Up StudiesHumansMalePolymorphism, Single NucleotidePrincipal Component AnalysisProspective StudiesReceptors, Complement 3bApolipoproteins ECR1 protein, humanReceptors, Complement 3bAscertainment biasBiasCohort studiesGeneticsGenome-wide association studiesGenome-wide studiesHome research study visitsInferenceLate-onset Alzheimer's diseaseLongitudinal studiesMissing dataPopulation-based studiesProspective studiesResearch clinic study visitsSelection bias

Identifiers

PMID28222301
PMCPMC5554082
OpenAlexW2532361908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.