ArticlePloS one2017
Emergence and development of gut motility in the chicken embryo.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Time-resolved morphological and transcriptomic characterization of early enteric neuron subtype emergence in chick.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine.Neurogastroenterology and motility · 2026Article
- Limited vertical transmission of microbiomes through the chorioallantoic membrane affects intestine development and metabolic pathways in broiler embryos.Frontiers in microbiology · 2026Article
- Three-dimensional-mapping of smooth muscle morphogenesis in the vertebrate gastrointestinal tract.Scientific reports · 2025Article
- Regulatory Mechanism of Intestinal Stem Cells Based on Hippo Pathway and Signaling Crosstalk in Chicken.International journal of molecular sciences · 2025Review
- Self-organized patterning of peristaltic waves by suppressive actions in a developing gut.Frontiers in cell and developmental biology · 2025Article
- Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation.Communications biology · 2024Article
- Optogenetic control of gut movements reveals peristaltic wave-mediated induction of cloacal contractions and reactivation of impaired gut motility.Frontiers in physiology · 2023Article
- High-resolution ultrasound and speckle tracking: a non-invasive approach to assess in vivo gastrointestinal motility during development.Development (Cambridge, England) · 2022Article
- Commentary: Localization of contractile wave nucleation sites as an emerging phenomenon of stochastic myogenic gut motility.Frontiers in cell and developmental biology · 2022Article
- Distribution Map of Peristaltic Waves in the Chicken Embryonic Gut Reveals Importance of Enteric Nervous System and Inter-Region Cross Talks Along the Gut Axis.Frontiers in cell and developmental biology · 2022Article
- A neural crest cell isotropic-to-nematic phase transition in the developing mammalian gut.Communications biology · 2021Article
- How Smooth Muscle Contractions Shape the Developing Enteric Nervous System.Frontiers in cell and developmental biology · 2021Article
- Integrating Bioelectrical Currents and CaBioelectricity · 2020Review
- Smooth muscle contractility causes the gut to grow anisotropically.Journal of the Royal Society, Interface · 2019Article
- Cellular Composition and Differentiation Signaling in Chicken Small Intestinal Epithelium.Animals : an open access journal from MDPI · 2019Review
- Article
- Embryogenesis of the peristaltic reflex.The Journal of physiology · 2019Article
- Smooth muscle: a stiff sculptor of epithelial shapes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- The first digestive movements in the embryo are mediated by mechanosensitive smooth muscle calcium waves.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gastrointestinal tract transports the food bolus by peristalsis. Gut motility starts at an early age in the developing embryo, well before it is required for nutrition of the organism. We present a comprehensive kinematic study of the emergence and physiological development of gut motility in all regions of the lower digestive tract of the chicken embryo from embryonic days E5 through E9. We characterized motility emergence time, propagation patterns, speed, frequency and amplitude of peristalsis waves. We found that the emergence of an uninterrupted circular ring of smooth muscle correlated with the appearance of propagative contractile waves, at E6 in the hindgut and midgut, and at E9 in the caecal appendix. We show that peristalsis at these stages is critically dependent on calcium and is not mediated by neurons as gut motility is insensitive to tetrodotoxin and takes place in the hindgut in the absence of neurons. We further demonstrate that motility also matures in ex-vivo organ culture. We compare our results to existing literature on zebrafish, mouse and human motility development, and discuss their chronological relationship with other major developmental events occurring in the chicken embryonic gut at these stages. Our work sets a baseline for further investigations of motility development in this important animal model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.