ArticlePLoS genetics2017
The genetic basis of resistance and matching-allele interactions of a host-parasite system: The Daphnia magna-Pasteuria ramosa model.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 80 citations in OpenAlex.
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- Aphid herbivory on macrophytes drives adaptive evolution in an aquatic community via indirect effects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Conceptual Disease Cycle Model to Link the Size of Past and Future Epidemics.Ecology and evolution · 2025Review
- Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen.G3 (Bethesda, Md.) · 2025Article
- The Evolution of Extreme Genetic Variability in a Parasite-Resistance Complex.Genome biology and evolution · 2024Article
- Inference of Host-Pathogen Interaction Matrices from Genome-Wide Polymorphism Data.Molecular biology and evolution · 2024Article
- Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins.PLoS neglected tropical diseases · 2024Article
- Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen.Nature communications · 2024Article
- A common multi-host parasite shows genetic structuring at the host species and population levels.Parasitology · 2024Article
- Ectopical expression of bacterial collagen-like protein supports its role as adhesin in host-parasite coevolution.Royal Society open science · 2024Article
- Uncovering the Genomic Basis of Infection Through Co-genomic Sequencing of Hosts and Parasites.Molecular biology and evolution · 2023Article
- Molecular mechanisms of adaptive evolution in wild animals and plants.Science China. Life sciences · 2023Review
- QTL study reveals candidate genes underlying host resistance in a Red Queen model system.PLoS genetics · 2023Article
- Rapid evolution of a bacterial parasite during outbreaks in twoEcology and evolution · 2023Article
- Genetic slippage after sex maintains diversity for parasite resistance in a natural host population.Science advances · 2022Article
- MHC class II genotype-by-pathogen genotype interaction for infection prevalence in a natural rodent-Borrelia system.Evolution; international journal of organic evolution · 2022Article
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Negative frequency-dependent selection (NFDS) is an evolutionary mechanism suggested to govern host-parasite coevolution and the maintenance of genetic diversity at host resistance loci, such as the vertebrate MHC and R-genes in plants. Matching-allele interactions of hosts and parasites that prevent the emergence of host and parasite genotypes that are universally resistant and infective are a genetic mechanism predicted to underpin NFDS. The underlying genetics of matching-allele interactions are unknown even in host-parasite systems with empirical support for coevolution by NFDS, as is the case for the planktonic crustacean Daphnia magna and the bacterial pathogen Pasteuria ramosa. We fine-map one locus associated with D. magna resistance to P. ramosa and genetically characterize two haplotypes of the Pasteuria resistance (PR-) locus using de novo genome and transcriptome sequencing. Sequence comparison of PR-locus haplotypes finds dramatic structural polymorphisms between PR-locus haplotypes including a large portion of each haplotype being composed of non-homologous sequences resulting in haplotypes differing in size by 66 kb. The high divergence of PR-locus haplotypes suggest a history of multiple, diverse and repeated instances of structural mutation events and restricted recombination. Annotation of the haplotypes reveals striking differences in gene content. In particular, a group of glycosyltransferase genes that is present in the susceptible but absent in the resistant haplotype. Moreover, in natural populations, we find that the PR-locus polymorphism is associated with variation in resistance to different P. ramosa genotypes, pointing to the PR-locus polymorphism as being responsible for the matching-allele interactions that have been previously described for this system. Our results conclusively identify a genetic basis for the matching-allele interaction observed in a coevolving host-parasite system and provide a first insight into its molecular basis.
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