Evidence map›Paper›PMID 28221763›Full record

ArticleACS nano2017

Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats.

Kian Fan Chung, Joanna Seiffert, Shu Chen, Ioannis G Theodorou, Angela Erin Goode, Bey Fen Leo, Catriona M McGilvery, Farhana Hussain, Coen Wiegman, Christos Rossios and 11 more

Abstract read
In one paragraph

Article in ACS nano, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Metal-Based Nanoparticles as Antimicrobial Agents: An Overview.Nanomaterials (Basel, Switzerland) · 2020
    Review
  7. Review
  8. Current approaches for safer design of engineered nanomaterials.Ecotoxicology and environmental safety · 2018
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Joanna Seiffert
Shu Chen
Ioannis G TheodorouORCID 0000-0002-9572-417X
Angela Erin Goode
Bey Fen LeoNanotechnology and Catalysis Research Centre (NANOCAT), University of Malaya , Kuala Lumpur 50603, Malaysia.
Catriona M McGilvery
Farhana Hussain
Coen Wiegman
Jie Zhu
Jicheng GongNicholas School of Environment and Duke Global Health Institute, Duke University , Durham, North Carolina 27708, United States.
Farid Tariq
Vladimir Yufit
Alexander J MonteithDepartment of Biological Sciences, Oxford Brookes University , Oxford OX3 OBP, United Kingdom.
Teruo HashimotoThe School of Materials, The University of Manchester , Oxford Road, Manchester M13 9PL, United Kingdom.
Jeremy N SkepperCambridge Advanced Imaging Centre, Department of Anatomy, University of Cambridge , Tennis Court Road, Cambridge CB2 3DY United Kingdom.
Mary P Ryan
Junfeng ZhangNicholas School of Environment and Duke Global Health Institute, Duke University , Durham, North Carolina 27708, United States.
Teresa D Tetley
Alexandra E Porter

Funding

Scientific CoreU19ES019536 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TETLEY, TERESA DOROTHY, ZHANG, JUNFENG · 2010 to 2014
$4.6M
NIEHS NIH HHS U19 ES019536
6 · The paper itself

Abstract

There is a potential for silver nanowires (AgNWs) to be inhaled, but there is little information on their health effects and their chemical transformation inside the lungs in vivo. We studied the effects of short (S-AgNWs; 1.5 μm) and long (L-AgNWs; 10 μm) nanowires instilled into the lungs of Sprague-Dawley rats. S- and L-AgNWs were phagocytosed and degraded by macrophages; there was no frustrated phagocytosis. Interestingly, both AgNWs were internalized in alveolar epithelial cells, with precipitation of Ag

Indexed as

AnimalsInstillation, DrugLungNanowiresRatsRats, Sprague-DawleySilverSilveralveolar epithelial cellsbronchial hyperresponsivenessmacrophagessilver nanowiressilver sulfidationsurfactant protein D

Identifiers

PMID28221763
PMCPMC5371928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.