Evidence map›Paper›PMID 28221710›Full record

ArticleDepression and anxiety2017

Mobile assessment of heightened skin conductance in posttraumatic stress disorder.

Rebecca Hinrichs, Vasiliki Michopoulos, Sterling Winters, Alex O Rothbaum, Barbara O Rothbaum, Kerry J Ressler, Tanja Jovanovic

Open access · bronzeAbstract read
In one paragraph

Article in Depression and anxiety, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 64 citations in OpenAlex.

  1. Trial
  2. Effects of behavioral interventions on stress reactivity in adults with substance use disorders.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
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  8. Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
  9. Article
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  15. Article
  16. The Impact of Sleep on Fear Extinction.Current topics in behavioral neurosciences · 2023
    Article
  17. Sex-dependent risk factors for PTSD: a prospective structural MRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  18. Biological Psychiatry in Displaced Populations: What We Know, and What We Need to Begin to Learn.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rebecca HinrichsDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Vasiliki MichopoulosDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Sterling WintersDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Alex O RothbaumDepartment of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
Barbara O RothbaumDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Kerry J ResslerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · USCase Western Reserve University · USEmory National Primate Research CenterMcLean Hospital · US

Funding

Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
Emory University BIRCWH ProgramK12HD085850 · NICHD · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, STERK, CLAIRE E · 2015 to 2023
$4.4M
2 of 2 Prospective Determination of Psychobiological Risk Factors for PTSDR01MH094757 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2012 to 2016
$2.3M
Biological Mechanisms of Stress Disorders Co-Morbid with HIV in African American WomenR01MH110364 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOVANOVIC, TANJA, NEIGH, GRETCHEN N · 2016 to 2020
$2.0M
Emory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4M
Prospective Determination of the Epigenetic Response to TraumaR21MH106902 · NIMH · EMORY UNIVERSITY · PI JOVANOVIC, TANJA, SMITH, ALICIA K · 2016 to 2017
$429k
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR000424NIAID NIH HHS R38 AI140299NIA NIH HHS U54 AG062334NICHD NIH HHS K12 HD085850NIMH NIH HHS R01 MH094757NIMH NIH HHS R01 MH110364NIMH NIH HHS R21 MH106902
6 · The paper itself

Abstract

backgroundIncreased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be easily used in a single visit. Thus, there is a need for a low-cost, easy-to-use, SC recording protocol for PTSD assessment.

methodsUsing a mobile device (eSense) connected to a portable tablet computer, we assessed SC reactivity to a standard trauma interview (STI) in 63 participants recruited from Grady Memorial Hospital in Atlanta, GA, approximately 1 year after trauma exposure. SC response (SCR) was calculated by subtracting the SC level (SCL) at the end of the baseline recording from the maximum SCL during the STI.

resultsSCL was significantly higher during the STI compared to baseline (P < .001), and individuals with PTSD showed significantly greater SCR than individuals without PTSD (P = .006). Logistic regression using SCR with PTSD diagnosis as the outcome showed an odds ratio of 1.76 (95% CI: 1.11-2.78). Lastly, higher SCR during the STI was also significantly associated with PTSD symptom total score controlling for demographics and trauma severity (b = 0.42, P = .001).

conclusionsThe current study demonstrated feasibility of the use of a mobile device for assessing psychophysiological reactivity in those with PTSD. The use of this low-cost, easy-to-use mobile device to collect objective physiological data in concert with a STI can be easily disseminated in clinical and research settings.

Indexed as

Mobile ApplicationsAdultFeasibility StudiesFemaleGalvanic Skin ResponseHumansInterview, PsychologicalMaleMonitoring, AmbulatoryStress Disorders, Post-Traumaticassessment/diagnosisbiological markersdissemination/implementationPTSD/posttraumatic stress disordertrauma

Identifiers

PMID28221710
PMCPMC5466496
OpenAlexW2589417566

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.