ArticleNature communications2017
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration.Clinical psychology review · 2021Pooled it
- The IMAGEN study: a decade of imaging genetics in adolescents.Molecular psychiatry · 2020Pooled it
- Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.Drug and alcohol dependence · 2020Trial
- Alcohol effects on globus pallidus connectivity: Role of impulsivity and binge drinking.PloS one · 2020Trial
- Reward and Imitation in Social Conformity.Brain and behavior · 2026Article
- Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity.Human brain mapping · 2026Article
- Trait reward sensitivity and behavioral motivation are associated with connectivity between the default mode network and the striatum during reward anticipation.Cognitive, affective & behavioral neuroscience · 2026Article
- Social closeness and reward sensitivity enhance corticostriatal function during experiences of shared rewards.Biological psychology · 2026Article
- Reimagining the biopsychosocial model: hierarchical mechanisms from transdiagnostic to precision psychiatry.Journal of psychiatry & neuroscience : JPN · 2026Review
- Unexpected Events Resist Directed Forgetting.Journal of cognitive enhancement : towards the integration of theory and practice · 2026Article
- From Pellets to Prizes: Preclinical and Clinical Perspectives on Contingency Management for the Treatment of Substance Use Disorder.Substance abuse and rehabilitation · 2026Review
- Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.Frontiers in adolescent medicine · 2026Article
- Trait reward sensitivity and behavioral motivation are associated with connectivity between the default mode network and the striatum during reward anticipation.bioRxiv : the preprint server for biology · 2025Article
- Review
- Social Closeness and Reward Sensitivity Enhance Corticostriatal Function during Experiences of Shared Rewards.bioRxiv : the preprint server for biology · 2025Article
- A Novel Diathesis-Stress Model of Comorbid Early Onset Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025Article
- A multimodal neuroimaging study of youth at risk for substance use disorders: Functional magnetic resonance imaging and [Alcohol, clinical & experimental research · 2025Article
- Unintended bias in the pursuit of collinearity solutions in fMRI analysis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors.Current opinion in neurobiology · 2024Review
- Higher substance use is associated with low executive control neural activity and higher inflammation.Brain, behavior, and immunity · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 20 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.