SynthesisJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases2017
Systematic Review and Meta-analysis of Interventions for Depression and Anxiety in Persons With Rheumatoid Arthritis.
Synthesis in Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Interventions for Depressive Symptoms in People Living with Chronic Pain: A Systematic Review of Meta-Analyses.Pain medicine (Malden, Mass.) · 2022Pooled it
- META analysis on the effect of taijiquan on improving negative psychological symptoms of college students and the optimal dose.Frontiers in public health · 2022Pooled it
- Systematic Review and Meta-analysis of Interventions for Depression and Anxiety in Persons With Rheumatoid Arthritis.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2017Pooled it
- The association of fatigue, pain, depression and anxiety with work and activity impairment in immune mediated inflammatory diseases.PloS one · 2018Trial
- Observational
- Cognitive impairment, depression, and anxiety in systemic sclerosis.Frontiers in medicine · 2026Article
- Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential.Biomolecules · 2025Review
- Predictors for health-related quality of life in patients with rheumatoid arthritis: a longitudinal study.Rheumatology advances in practice · 2025Article
- An integrated approach to the treatment of Rheumatic diseases: the role of psychological interventions.Rheumatology international · 2024Review
- Health-related quality of life (HRQoL) loss associated with self-perceived anxiety/depression in seropositive rheumatoid arthritis.Clinical rheumatology · 2024Article
- Impact of inflammation on cognitive function in patients with highly inflammatory rheumatoid arthritis.RMD open · 2024Article
- Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF.Neuroscience bulletin · 2024Article
- A neural circuit associated with anxiety-like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture.CNS neuroscience & therapeutics · 2024Article
- Association between sociodemographic factors, clinic characteristics and mental health screening rates in primary care.PloS one · 2024Article
- Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- 3D-Printed Ergonomically Designed Feeding Aid for Patients With Limited Manual Dexterity.Cureus · 2023Article
- The Effectiveness of Psychological Interventions for Rheumatoid Arthritis (RA): A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2023Review
- Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms in Rheumatoid Arthritis Patients: A Cross-sectional Study.Clinical practice and epidemiology in mental health : CP & EMH · 2023Article
- Depression in Rheumatoid Arthritis: A Narrative Review-Diagnostic Challenges, Pathogenic Mechanisms and Effects.Medicina (Kaunas, Lithuania) · 2022Review
- Customized Pen for Patients With Arthritis.Cureus · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychiatric comorbidities, such as depression and anxiety, are very common in persons with rheumatoid arthritis (RA) and can lead to adverse outcomes. By appropriately treating these comorbidities, disease-specific outcomes and quality of life may be improved.
objectiveThe aim of this study was to systematically review the literature from controlled trials of treatments for depression and anxiety in persons with RA.
methodsWe searched multiple online databases from inception until March 25, 2015, without restrictions on language, date, or location of publication. We included controlled trials conducted in persons with RA and depression or anxiety. Two independent reviewers extracted information including trial and participant characteristics. The standardized mean differences (SMDs) of depression or anxiety scores at postassessment were pooled between treatment and comparison groups, stratified by active versus inactive comparators.
resultsFrom 1291 unique abstracts, we included 8 RA trials of depression interventions (6 pharmacological, 1 psychological, 1 both). Pharmacological interventions for depression with inactive comparators (n = 3 trials, 143 participants) did not reduce depressive symptoms (SMD, -0.21; 95% confidence interval [CI], -1.27 to 0.85), although interventions with active comparators (n = 3 trials, 190 participants) did improve depressive symptoms (SMD, -0.79; 95% CI, -1.34 to -0.25). The single psychological trial of depression treatment in RA did not improve depressive symptoms (SMD, -0.44; 95% CI, -0.96 to 0.08). Seven of the trials had an unclear risk of bias.
conclusionsFew trials examining interventions for depression or anxiety in adults with RA exist, and the level of evidence is low to moderate because of the risk of bias and small number of trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.