Evidence map›Paper›PMID 28221286›Full record

ReviewPain2017

Sickle cell disease: a natural model of acute and chronic pain.

Amanda M Brandow, Katherine J Zappia, Cheryl L Stucky

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03899246 phase1completednot on this mapstarted 2019, after this paper: background citation

Safety and Feasibility of High-Dose Topical Capsaicin for the Treatment of Neuropathic Pain in Pediatric Sickle Cell Disease

TypeinterventionalSponsorChildren's Hospital of MichiganRan2019 to 2020Enrolled10ConditionsNeuropathic Pain, Sickle Cell DiseaseArmsEight Percent Topical Capsaicin
NCT04917783 nacompletednot on this mapstarted 2019, after this paper: background citation

Health Literacy: A Randomized Controlled Trial to Investigate a Novel Feedback Tool for Neurocognitive Screening in Pediatric Sickle Cell Disease

TypeinterventionalSponsorMedical College of WisconsinRan2019 to 2021Enrolled46ConditionsSickle Cell DiseaseArmsPassport Card, No Passport card
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Antioxidant supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Dyslipidemia is a metabolic hallmark of acute pain in sickle cell disease.medRxiv : the preprint server for health sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Chronic pain in the aging adult with sickle cell disease.Frontiers in pain research (Lausanne, Switzerland) · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amanda M BrandowDepartment of Pediatrics, Section of Pediatric Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
Katherine J ZappiaDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.
Cheryl L StuckyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Funding

Nociceptive Mechanisms Underlying Sickle Cell PainR01NS070711 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI Bonnie N Dittel, Cheryl Louise Stucky · 2009 to 2026
$8.7M
FUNCTIONAL ANALYSIS OF DISTINCT NOCICEPTOR POPULATIONSR01NS040538 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI STUCKY, CHERYL LOUISE · 2000 to 2019
$6.2M
Peripheral Sensitization as a Novel Mechanism for Pain in Sickle Cell DiseaseK23HL114636 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BRANDOW, AMANDA M · 2013 to 2017
$752k
The Role of Chemokine Signaling in Sickle Cell PainF31NS087716 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI ZAPPIA, KATHERINE JAHNELLE HENDLEY · 2014 to 2015
$81k
NHLBI NIH HHS K23 HL114636NHLBI NIH HHS L40 HL086340NINDS NIH HHS F31 NS087716NINDS NIH HHS R01 NS040538NINDS NIH HHS R01 NS070711
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute PainAnemia, Sickle CellAnimalsChronic PainHumans

Identifiers

PMID28221286
PMCPMC5350013

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.