ArticleEmerging infectious diseases2017
Mycobacterium tuberculosis Transmission among Elderly Persons, Yamagata Prefecture, Japan, 2009-2015.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 81 citations in OpenAlex.
- Mutations in sugar metabolism-related genes driving global drug-resistant Mycobacterium tuberculosis transmission revealed by whole-genome sequencing.BMC infectious diseases · 2026Article
- The impact of population ageing on tuberculosis incidence, mortality, and case fatality in South Korea: a nationwide retrospective study.ERJ open research · 2025Article
- [Molecular Epidemiological Analysis of Tuberculosis Transmission in Households in Republic of Korea, 2016-2024].Jugan geon-gang gwa jilbyeong · 2025Article
- Tuberculosis Incidence and Outcomes Among Older New Yorkers.Open forum infectious diseases · 2025Article
- Association of mutations in Mycobacterium tuberculosis complex (MTBC) respiration chain genes with hyper-transmission.BMC genomics · 2024Article
- Iron-related gene mutations driving global Mycobacterium tuberculosis transmission revealed by whole-genome sequencing.BMC genomics · 2024Article
- Toxin-antitoxin system gene mutations drivingFrontiers in microbiology · 2024Article
- Association between two-component systems gene mutation and Mycobacterium tuberculosis transmission revealed by whole genome sequencing.BMC genomics · 2023Article
- Tuberculosis in older adults: challenges and best practices in the Western Pacific Region.The Lancet regional health. Western Pacific · 2023Review
- Tuberculosis in older adults: case studies from four countries with rapidly ageing populations in the western pacific region.BMC public health · 2023Article
- Epidemiological features of tuberculosis infection in a rural prefecture of Japan from 2007 to 2018.Scientific reports · 2022Article
- Delayed diagnosis of active pulmonary tuberculosis - potential risk factors for patient and healthcare delays in Portugal.BMC public health · 2021Article
- Pulmonary Tuberculosis in Older Adults: Increased Mortality Related to Tuberculosis Within Two Months of Treatment Initiation.Drugs & aging · 2021Article
- Estimating the burden of nosocomial exposure to tuberculosis in South Korea, a nationwide population based cross-sectional study.The Korean journal of internal medicine · 2021Article
- Time to diagnosis of tuberculosis is greater in older patients: a retrospective cohort review.ERJ open research · 2019Article
- Mathematical modelling of the impact of treating latent tuberculosis infection in the elderly in a city with intermediate tuberculosis burden.Scientific reports · 2019Article
- Delay from symptom onset to treatment start among tuberculosis patients in England, 2012-2015.Epidemiology and infection · 2018Article
- Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2018Article
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7 authors at 2 institutions in 1 country.
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Abstract
In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted to elderly persons. It is unclear, however, whether these cases are associated with recent Mycobacterium tuberculosis transmission or represent reactivation of past disease. During 2009-2015, we performed a population-based TB investigation in Yamagata Prefecture, Japan, using in-depth contact tracing and 24-loci variable-number tandem-repeat typing optimized for Beijing family M. tuberculosis strains. We analyzed 494 strains, of which 387 (78.3%) were derived from elderly patients. Recent transmission with an epidemiologic link was confirmed in 22 clusters (70 cases). In 17 (77.3%) clusters, the source patient was elderly; 11 (64.7%) of the 17 clusters occurred in a hospital or nursing home. In this setting, the increase in TB cases was associated with M. tuberculosis transmissions from elderly persons. Prevention of transmission in places where elderly persons gather will be an effective strategy for decreasing TB incidence among predominantly elderly populations.
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