ArticleGenes, brain, and behavior2017
Drosophila divalent metal ion transporter Malvolio is required in dopaminergic neurons for feeding decisions.
Article in Genes, brain, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Genetic dissection of signalling pathways that mediate iron-related tumor growth in a Drosophila model.PLoS genetics · 2026Article
- From phenotype to genotype: the precursor hypothesis predicts genetic influences that facilitate transitions in social behavior.Current opinion in insect science · 2019Review
- UsingFrontiers in cellular neuroscience · 2018Review
- Identification of Candidate Iron Transporters From the ZIP/ZnT Gene Families in the MosquitoFrontiers in physiology · 2018Article
- The Impact of Environmental Mn Exposure on Insect Biology.Frontiers in genetics · 2018Review
- Duplication and Sub/Neofunctionalization ofG3 (Bethesda, Md.) · 2017Article
- How micronutrients influence the physiology of mosquitoes.Current opinion in insect science · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Members of the natural resistance-associated macrophage protein (NRAMP) family are evolutionarily conserved metal ion transporters that play an essential role in regulating intracellular divalent cation homeostasis in both prokaryotes and eukaryotes. Malvolio (Mvl), the sole NRAMP family member in insects, plays a role in food choice behaviors in Drosophila and other species. However, the specific physiological and cellular processes that require the action of Mvl for appropriate feeding decisions remain elusive. Here, we show that normal food choice requires Mvl function specifically in the dopaminergic system, and can be rescued by supplementing food with manganese. Collectively, our data indicate that the action of the Mvl transporter affects food choice behavior via the regulation of dopaminergic innervation of the mushroom bodies, a principle brain region associated with decision-making in insects. Our studies suggest that the homeostatic regulation of the intraneuronal levels of divalent cations plays an important role in the development and function of the dopaminergic system and associated behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.