Evidence map›Paper›PMID 28220995›Full record

ReviewBiotechnology journal2017

Development of hydrogels for regenerative engineering.

Xiaofei Guan, Meltem Avci-Adali, Emine Alarçin, Hao Cheng, Sara Saheb Kashaf, Yuxiao Li, Aditya Chawla, Hae Lin Jang, Ali Khademhosseini

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 196 citations in OpenAlex.

  1. Review
  2. Polynucleotide HPTAntioxidants (Basel, Switzerland) · 2025
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  5. Review
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  13. Article
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  15. Review
  16. Review
  17. Next-generation biomaterials for dental pulp tissue immunomodulation.Dental materials : official publication of the Academy of Dental Materials · 2023
    Review
  18. Review
  19. Methodology for characterizing the printability of hydrogels.International journal of bioprinting · 2023
    Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 6 countries.

Xiaofei GuanDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Meltem Avci-AdaliDepartment of Thoracic and Cardiovascular Surgery, University Hospital Tuebingen, Tuebingen, Germany.
Emine AlarçinDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Hao ChengDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Sara Saheb KashafDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Yuxiao LiDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Aditya ChawlaDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Hae Lin JangDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Ali KhademhosseiniDivision of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, MA 02139, Boston, MA, USA.
Harvard University · USMassachusetts Institute of Technology · USBrigham and Women's Hospital · USInnovation Research Center · USMarmara University · TRShanghai Tenth People's Hospital · CNSTZ eyetrial · DE

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
Whitlockite nanoparticles for inducing bone regenerationR21AR070647 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2016 to 2017
$423k
NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R21 AR070647
6 · The paper itself

Abstract

The aim of regenerative engineering is to restore complex tissues and biological systems through convergence in the fields of advanced biomaterials, stem cell science, and developmental biology. Hydrogels are one of the most attractive biomaterials for regenerative engineering, since they can be engineered into tissue mimetic 3D scaffolds to support cell growth due to their similarity to native extracellular matrix. Advanced nano- and micro-technologies have dramatically increased the ability to control properties and functionalities of hydrogel materials by facilitating biomimetic fabrication of more sophisticated compositions and architectures, thus extending our understanding of cell-matrix interactions at the nanoscale. With this perspective, this review discusses the most commonly used hydrogel materials and their fabrication strategies for regenerative engineering. We highlight the physical, chemical, and functional modulation of hydrogels to design and engineer biomimetic tissues based on recent achievements in nano- and micro-technologies. In addition, current hydrogel-based regenerative engineering strategies for treating multiple tissues, such as musculoskeletal, nervous and cardiac tissue, are also covered in this review. The interaction of multiple disciplines including materials science, cell biology, and chemistry, will further play an important role in the design of functional hydrogels for the regeneration of complex tissues.

Indexed as

AnimalsBiomedical ResearchHumansHydrogelsMiceNanomedicineNanoparticlesRegenerative MedicineTissue EngineeringHydrogelsBiofabricationHydrogelNanotechnologyRegenerative engineeringTissue regeneration

Identifiers

PMID28220995
PMCPMC5503693
OpenAlexW2589394758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.