Evidence map›Paper›PMID 28220990›Full record

ArticleGenes, brain, and behavior2017

Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome.

N F Sharif, Z Korade, N A Porter, F E Harrison

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Sterol biosynthesis, brain development, and disease.The Journal of clinical investigation · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Mutations in the zebrafishBlood advances · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

N F SharifNeuroscience Program, Vanderbilt University, Nashville, TN, USA.
Z KoradeDepartment of Psychiatry, Vanderbilt University, Nashville, TN, USA.
N A PorterDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
F E HarrisonDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1121-0647
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Stress-Mediated Alterations in Serotonin 2C Receptor Editing and FunctionP50MH096972 · NIMH · VANDERBILT UNIVERSITY · PI BLAKELY, RANDY D. · 2012 to 2016
$10.5M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
SLOS and Neuronal Oxidative StressR01HD064727 · NICHD · VANDERBILT UNIVERSITY · PI PORTER, NED ALLEN · 2010 to 2020
$3.7M
Vitamin C and cognition in Alzheimer's diseaseR01AG038739 · NIA · VANDERBILT UNIVERSITY · PI HARRISON, FIONA EDITH · 2011 to 2014
$1.1M
Sterols, Neurogenesis and Environmental AgentsR01ES024133 · NIEHS · VANDERBILT UNIVERSITY · PI KORADE, ZELJKA, PORTER, NED ALLEN · 2015 to 2017
$1.1M
NIA NIH HHS R01 AG038739NICHD NIH HHS R01 HD064727NICHD NIH HHS U54 HD083211NIDDK NIH HHS P30 DK020593NIEHS NIH HHS R01 ES024133NIMH NIH HHS P50 MH096972
6 · The paper itself

Abstract

Smith-Lemli-Opitz syndrome is an inherited monogenic disorder in which mutations to the 7-dehydrocholesterol (7-DHC) reductase (Dhcr7) gene lead to deficits in cholesterol synthesis. As a result, many patients suffer from gross physiological and neurological deficits. The purpose of this study was to identify a potential abnormal behavioral phenotype in a compound mutant mouse model for Smith-Lemli-Opitz disease (Dhcr7

Indexed as

Oxidative StressVocalization, AnimalAnimalsBrainDehydrocholesterolsFemaleHeterozygoteMaleMiceOxidoreductases Acting on CH-CH Group DonorsSerotoninSerotonin Plasma Membrane Transport ProteinsSmith-Lemli-Opitz SyndromeUltrasonic Waves7-dehydrocholesterol7-dehydrocholesterol reductaseDehydrocholesterolsOxidoreductases Acting on CH-CH Group DonorsSerotoninSerotonin Plasma Membrane Transport ProteinsAntioxidantdevelopmentDhcr7mouse modeloxysterolsserotoninSERTSmith-Lemli-Opitz syndromeultrasonic vocalizationsvitamin E

Identifiers

PMID28220990
PMCPMC5495606
OpenAlexW2589595145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.