ArticleScientific reports2017
Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory status.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Oral Microbiome and Metabolome Changes During Orthodontic Treatments: A Systematic Review of Limited Clinical Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review.Clinical and experimental dental research · 2025Pooled it
- Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Periodontal disease metabolomics signatures from different biofluids: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2022Pooled it
- Salivary metabolomics for the diagnosis of periodontal diseases: a systematic review with methodological quality assessment.Metabolomics : Official journal of the Metabolomic Society · 2021Pooled it
- Discriminating high-risk cervical Human Papilloma Virus infections with urinary biomarkers via non-targeted GC-MS-based metabolomics.PloS one · 2018Trial
- The immune-microbe-metal triad: a vicious cycle driving biomaterial corrosion in the oral inflammatory microenvironment.Bioactive materials · 2027Review
- Longitudinal development of infant oral ecosystem: salivary metabolomic, bacteriome, and virome dynamics in early infancy.mSystems · 2026Article
- Metabolomic analysis of gingival crevicular fluid for dental age and skeletal maturity assessment in growing individuals.European journal of orthodontics · 2026Article
- The synergistic pro-inflammatory effect of butyric and propionic acid on human periodontal ligament cells via activation of G-protein-coupled receptor 41.Journal of periodontal & implant science · 2026Article
- Diabetes alters the supragingival microbiome through plasma-to-saliva migration of glucose and fructose.Microbiome · 2025Article
- Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Metabolomic and metagenomic analyses reveal distinct microenvironmental signatures between clear aligner-associated and tooth surface dental plaque.BMC oral health · 2025Article
- Accuracy of Metabolomics in Peri-Implant Crevicular Fluid for Diagnosis and Prognosis of Peri-Implantitis.Journal of periodontal research · 2025Article
- Unveiling Oral Health Impacts of Vaping in African Americans through Untargeted Metabolomics and Proteomics.Environment & health (Washington, D.C.) · 2025Article
- Metabolomics Applications for Diagnosing Peri-Implantitis: A Systematic Review of In Vivo Studies.Diagnostics (Basel, Switzerland) · 2025Review
- A Comparative Study of Network-Based Machine Learning Approaches for Binary Classification in Metabolomics.Metabolites · 2025Article
- Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease.BMC oral health · 2025Article
- Analysis of the diversity and function of the microbiota in infected root canals of type 2 diabetes mellitus with apical periodontitis.Frontiers in cellular and infection microbiology · 2025Article
- Hyperuricemia and elevated uric acid/creatinine ratio are associated with stages III/IV periodontitis: a population-based cross-sectional study (NHANES 2009-2014).BMC oral health · 2024Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as an emergent property. The purpose of this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we investigated disease-associated metabolic signatures of periodontal microbiota using a salivary metabolomics approach. Whole saliva samples were obtained from adult subjects before and after removal of supragingival plaque (debridement). Periodontal inflamed surface area (PISA) was employed as an indicator of periodontal inflammatory status. Based on multivariate analyses using pre-debridement salivary metabolomics data, we found that metabolites associated with higher PISA included cadaverine and hydrocinnamate, while uric acid and ethanolamine were associated with lower PISA. Next, we focused on dental plaque metabolic byproducts by selecting salivary metabolites significantly decreased following debridement. Metabolite set enrichment analysis revealed that polyamine metabolism, arginine and proline metabolism, butyric acid metabolism, and lysine degradation were distinctive metabolic signatures of dental plaque in the high PISA group, which may be related to the metabolic signatures of disease-associated communities. Collectively, our findings identified potential biomarkers of periodontal inflammatory status and also provide insight into metabolic signatures of dysbiotic communities.
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Registered trials
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