ArticleScientific reports2017
Epigenetic determinants of space radiation-induced cognitive dysfunction.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Integrated analysis of metabolomics combined and net-work pharmacology reveals the effects of dexmedetomidine on early postoperative cognitive dysfunction in elderly patients: randomized controlled trial.BMC anesthesiology · 2025Trial
- Neurocognitive and neurobiological effects of low dose organophosphate exposure.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Disruption of DNA methylation underpins the neuroinflammation induced by targeted CNS radiotherapy.Brain : a journal of neurology · 2025Article
- Mission SpaceX CRS-16 RRRM-1 space flight induced skin genomic plasticity via an epigenetic trigger.iScience · 2024Article
- Irradiation and Alterations in Hippocampal DNA Methylation.Epigenomes · 2024Review
- Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation.Scientific reports · 2024Article
- Complex 33-beam simulated galactic cosmic radiation exposure impacts cognitive function and prefrontal cortex neurotransmitter networks in male mice.Nature communications · 2023Article
- Irradiation and lithium treatment alter the global DNA methylation pattern and gene expression underlying a shift from gliogenesis towards neurogenesis in human neural progenitors.Translational psychiatry · 2023Article
- New Radiobiological Principles for the CNS Arising from Space Radiation Research.Life (Basel, Switzerland) · 2023Article
- BDNF Augmentation Using Riluzole Reverses Doxorubicin-Induced Decline in Cognitive Function and Neurogenesis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine.Frontiers in physiology · 2023Review
- Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro-oncology.Journal of neuroscience research · 2022Review
- All for one, though not one for all: team players in normal tissue radiobiology.International journal of radiation biology · 2022Review
- Review
- Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation.Current neuropharmacology · 2022Review
- Quantitative proteomic analytic approaches to identify metabolic changes in the medial prefrontal cortex of rats exposed to space radiation.Frontiers in physiology · 2022Article
- Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System.International journal of molecular sciences · 2021Article
- Adenosine kinase: An epigenetic modulator in development and disease.Neurochemistry international · 2021Review
- Systemic HDAC3 inhibition ameliorates impairments in synaptic plasticity caused by simulated galactic cosmic radiation exposure in male mice.Neurobiology of learning and memory · 2021Article
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Among the dangers to astronauts engaging in deep space missions such as a Mars expedition is exposure to radiations that put them at risk for severe cognitive dysfunction. These radiation-induced cognitive impairments are accompanied by functional and structural changes including oxidative stress, neuroinflammation, and degradation of neuronal architecture. The molecular mechanisms that dictate CNS function are multifaceted and it is unclear how irradiation induces persistent alterations in the brain. Among those determinants of cognitive function are neuroepigenetic mechanisms that translate radiation responses into altered gene expression and cellular phenotype. In this study, we have demonstrated a correlation between epigenetic aberrations and adverse effects of space relevant irradiation on cognition. In cognitively impaired irradiated mice we observed increased 5-methylcytosine and 5-hydroxymethylcytosine levels in the hippocampus that coincided with increased levels of the DNA methylating enzymes DNMT3a, TET1 and TET3. By inhibiting methylation using 5-iodotubercidin, we demonstrated amelioration of the epigenetic effects of irradiation. In addition to protecting against those molecular effects of irradiation, 5-iodotubercidin restored behavioral performance to that of unirradiated animals. The findings of this study establish the possibility that neuroepigenetic mechanisms significantly contribute to the functional and structural changes that affect the irradiated brain and cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.