ArticleScientific reports2017
Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- In vitro and in vivo models for androgenetic alopecia drug development.Disease models & mechanisms · 2026Review
- Hair Follicle Organoids Using Human iPSC-Derived Ectodermal Precursor Cells for Hair Regenerative Medicine.ACS biomaterials science & engineering · 2026Article
- Quercetin rescues dihydrotestosterone-treated human dermal papilla cells via SHP2/AKT signaling to suppress autophagy and apoptosis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Review
- Functional regeneration strategies of hair follicles: advances and challenges.Stem cell research & therapy · 2025Review
- Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies.Frontiers in cell and developmental biology · 2025Review
- Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.Cells · 2024Review
- Materials-based hair follicle engineering: Basic components and recent advances.Materials today. Bio · 2024Review
- Review
- Ideal Living Skin Equivalents, From Old Technologies and Models to Advanced Ones: The Prospects for an Integrated Approach.BioMed research international · 2024Review
- Status of research on the development and regeneration of hair follicles.International journal of medical sciences · 2024Review
- Effects of oxytocin on the hair growth ability of dermal papilla cells.Scientific reports · 2023Article
- Trajectory of hiPSCs derived neural progenitor cells differentiation into dermal papilla-like cells and their characteristics.Scientific reports · 2023Article
- Male pattern hair loss: Can developmental origins explain the pattern?Experimental dermatology · 2023Article
- iPSC-based approach for human hair follicle regeneration.Frontiers in cell and developmental biology · 2023Review
- Reprogramming stem cells in regenerative medicine.Smart medicine · 2022Review
- Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration.Regenerative therapy · 2022Review
- Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness.eLife · 2022Article
- JAM-A facilitates hair follicle regeneration in alopecia areata through functioning as ceRNA to protect VCAN expression in dermal papilla cells.Precision clinical medicine · 2022Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dermal papilla (DP) is a specialised mesenchymal component of the hair follicle (HF) that plays key roles in HF morphogenesis and regeneration. Current technical difficulties in preparing trichogenic human DP cells could be overcome by the use of highly proliferative and plastic human induced pluripotent stem cells (hiPSCs). In this study, hiPSCs were differentiated into induced mesenchymal cells (iMCs) with a bone marrow stromal cell phenotype. A highly proliferative and plastic LNGFR(+)THY-1(+) subset of iMCs was subsequently programmed using retinoic acid and DP cell activating culture medium to acquire DP properties. The resultant cells (induced DP-substituting cells [iDPSCs]) exhibited up-regulated DP markers, interacted with human keratinocytes to up-regulate HF related genes, and when co-grafted with human keratinocytes in vivo gave rise to fibre structures with a hair cuticle-like coat resembling the hair shaft, as confirmed by scanning electron microscope analysis. Furthermore, iDPSCs responded to the clinically used hair growth reagent, minoxidil sulfate, to up-regulate DP genes, further supporting that they were capable of, at least in part, reproducing DP properties. Thus, LNGFR(+)THY-1(+) iMCs may provide material for HF bioengineering and drug screening for hair diseases.
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