ArticleScientific reports2017
On the Long-term Stability of Clines in Some Metabolic Genes in Drosophila melanogaster.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinal variation in natural populations of Drosophila melanogaster: An old debate about natural selection and neutral processes.Genetics and molecular biology · 2024Article
- Wolbachia reduces virus infection in a natural population of Drosophila.Communications biology · 2021Article
- Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.Molecular ecology · 2021Article
- Genomic Responses to Climate Change: Making the Most of theFrontiers in genetics · 2021Article
- Fitness effects but no temperature-mediated balancing selection at the polymorphicProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.Evolution; international journal of organic evolution · 2019Article
- How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.Molecular ecology · 2019Article
- Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations.Scientific reports · 2018Article
- The Effect of Common Inversion PolymorphismsG3 (Bethesda, Md.) · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Very little information exists for long-term changes in genetic variation in natural populations. Here we take the unique opportunity to compare a set of data for SNPs in 15 metabolic genes from eastern US collections of Drosophila melanogaster that span a large latitudinal range and represent two collections separated by 12 to 13 years. We also expand this to a 22-year interval for the Adh gene and approximately 30 years for the G6pd and Pgd genes. During these intervals, five genes showed a statistically significant change in average SNP allele frequency corrected for latitude. While much remains unchanged, we see five genes where latitudinal clines have been lost or gained and two where the slope significantly changes. The long-term frequency shift towards a southern favored Adh S allele reported in Australia populations is not observed in the eastern US over a period of 21 years. There is no general pattern of southern-favored or northern-favored alleles increasing in frequency across the genes. This observation points to the fluid nature of some allelic variation over this time period and the action of selective responses or migration that may be more regional than uniformly imposed across the cline.
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