Evidence map›Paper›PMID 28220794›Full record

ArticleScientific reports2017

Flucrypyrim, a novel uterine relaxant, has antinociceptive and anti-inflammatory effects in vivo.

Zhongtang Li, Limei Wang, Yue Cong, Lin Guo, Xiaohui Lin, Zuyin Yu, Xingan Wu, Junxing Dong, Rifang Yang, Yuwen Cong

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zhongtang LiDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Limei WangDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Yue CongDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Lin GuoDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Xiaohui LinDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Zuyin YuDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Xingan WuDepartment of Microbiology, Fourth Military Medical University, 17 Changle Xi Road, Xi'an, Shaanxi Province, 710032, PR China.
Junxing DongDepartment of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China.
Rifang YangDepartment of Medicinal Chemistry, Beijing Institute of Pharmacology and Toxicology, Beijing, China.
Yuwen CongDepartment of Pathophysiology, Beijing Institute of Radiation Medicine, Beijing, China.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consequences of primary dsysmenorrhea (PD) can be severe. Increased prostaglandin production leads to uterine contraction and insufficient blood flow to the endometrium causing ischemia and pain symptoms. Protein tyrosine kinase/phosphatase activities contribute to the modulation of uterine contraction. In our previous study, we found the synthetic β-methoxyacrylates compound Fluacrypyrim (FAPM), significantly increased protein tyrosine phosphatases (PTPs) activity, resulting in dephosphorylation of tyrosine kinases. In the present study, we found that FAPM near completely inhibited prostaglandin F2α (PGF

Indexed as

Nociceptive PainAcrylatesAnalgesicsAnimalsAnti-Inflammatory AgentsDinoprostMicePyrimidinesRatsStructure-Activity RelationshipUterine ContractionAcrylatesAnalgesicsAnti-Inflammatory AgentsDinoprostfluacrypyrimPyrimidines

Identifiers

PMID28220794
PMCPMC5318994
OpenAlexW2589801904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.