ArticleOrganic letters2017
N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction.The Journal of organic chemistry · 2026Article
- Innovative synthesis of drug-like molecules using tetrazole as core building blocks.Beilstein journal of organic chemistry · 2024Article
- Ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate in the smiles rearrangement reaction: straightforward synthesis of amino acid derived quinolin-2(1H)-one enamines.Molecular diversity · 2023Article
- Ugi Four-Component Reactions Using Alternative Reactants.Molecules (Basel, Switzerland) · 2023Review
- Copper(II)-β-cyclodextrin immobilized on graphitic carbon nitride nanosheets as a highly effective catalyst for tandem oxidative amidation of benzylic alcohols.Scientific reports · 2022Article
- Passerini-type reaction of boronic acids enables α-hydroxyketones synthesis.Nature communications · 2021Article
- Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents.Scientific reports · 2020Article
- Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles.Beilstein journal of organic chemistry · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reaction. Thus, N-hydroxyimide is added as a new acid component in the Ugi reaction and broadens the scaffold diversity.
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Registered trials
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