SynthesisAddiction (Abingdon, England)2017
The relationship between different dimensions of alcohol use and the burden of disease-an update.
Synthesis in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05580549 (Prevalence of Hazardous Alcohol Use in a Population With Hypertension in Primary Care Detected With PEth and AUDIT - Observational Cross-sectional Study), which is not on this map. Cited by 592 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence of Hazardous Alcohol Use in a Population With Hypertension in Primary Care Detected With PEth and AUDIT - Observational Cross-sectional Study
Who cites it
592 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,159 citations in OpenAlex.
- A review of the relationship between dimensions of alcohol consumption and the burden of disease: 2026 update including Mendelian randomisation studies.Addiction (Abingdon, England) · 2026Pooled it
- The Effects of Transcranial Magnetic Stimulation on Alcohol Craving, Efficacy, Emotion, and Cognitive Function in Patients With Alcohol Use Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.Brain and behavior · 2026Pooled it
- Moderate alcohol consumption and clinical outcomes in MASLD: a systematic review and meta-analysis of longitudinal cohorts.BMC gastroenterology · 2026Pooled it
- The association of parental or caregiver alcohol use with child maltreatment: A systematic review and meta-analysis of longitudinal studies.Addiction (Abingdon, England) · 2025Pooled it
- The risk relationships between alcohol consumption, alcohol use disorder and alcohol use disorder mortality: A systematic review and meta-analysis.Addiction (Abingdon, England) · 2024Pooled it
- Alcohol Exposure and Disease Associations: A Mendelian Randomization and Meta-Analysis on Weekly Consumption and Problematic Drinking.Nutrients · 2024Pooled it
- A burden of proof study on alcohol consumption and ischemic heart disease.Nature communications · 2024Pooled it
- Alcohol craving under stress in healthy young men: A randomized laboratory study.Alcohol, clinical & experimental research · 2026Trial
- Individual placement and support (IPS) integrated with specialized substance use disorder treatment: a socioeconomic analysis based on a randomized controlled trial.International journal of public health · 2026Trial
- Trial
- The effectiveness of a drink-counting and a breathalyser-coupled smartphone application for reduced heavy drinking among alcohol-dependent adults in Sweden: A randomised controlled trial.Addiction (Abingdon, England) · 2025Trial
- Baseline gut microbiome and metabolites are correlated with changes in alcohol consumption in participants in a randomized Zonisamide clinical trial.Scientific reports · 2025Trial
- Individualized treatment effects of a digital alcohol intervention and their associations with participant characteristics and engagement.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Trial
- The macroeconomic burden of four alcohol-attributable diseases in China, 1990-2023, and projections to 2030: results from GBD 2023.Annals of medicine · 2026Article
- Sex-specific neural activation to stress and alcohol cues in high-risk drinkers: links between orbitofrontal circuits, alcohol craving, and future drinking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Drinking patterns and antidepressant medication - a prospective register-linked study among 40 to 60-year-old employees.Social psychiatry and psychiatric epidemiology · 2026Article
- 'What's on the label?' - the uptake and distribution of alcohol warning labels in Dublin retail stores following delay in policy implementation.Preventive medicine reports · 2026Article
- Social Media Constructions of Alcohol as Emotional Coping and Social Connection in Ghana: Qualitative Study.JMIR infodemiology · 2026Article
- Mixing Energy Drinks with Alcohol is Related to Alcohol Problems Over Time Among Reserve and National Guard Soldiers.Military medicine · 2026Article
- A Role for Glycine Transporter-2 Inhibitors in Regulating Accumbal Dopamine Levels and Voluntary Alcohol Intake in Rats.Alcohol, clinical & experimental research · 2026Article
532 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 8 countries.
Funding
Abstract
BACKGROUND AND
aimsAlcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative Risk Assessments (CRAs).
methodsSystematic review of reviews and meta-analyses on alcohol consumption and health outcomes attributable to alcohol use. For dimensions of exposure: volume of alcohol use, blood alcohol concentration and patterns of drinking, in particular heavy drinking occasions were studied. For liver cirrhosis, quality of alcohol was additionally considered. For all outcomes (mortality and/or morbidity): cause of death and disease/injury categories based on International Classification of Diseases (ICD) codes used in global CRAs; harm to others.
resultsIn total, 255 reviews and meta-analyses were identified. Alcohol use was found to be linked causally to many disease and injury categories, with more than 40 ICD-10 three-digit categories being fully attributable to alcohol. Most partially attributable disease categories showed monotonic relationships with volume of alcohol use: the more alcohol consumed, the higher the risk of disease or death. Exceptions were ischaemic diseases and diabetes, with curvilinear relationships, and with beneficial effects of light to moderate drinking in people without heavy irregular drinking occasions. Biological pathways suggest an impact of heavy drinking occasions on additional diseases; however, the lack of medical epidemiological studies measuring this dimension of alcohol use precluded an in-depth analysis. For injuries, except suicide, blood alcohol concentration was the most important dimension of alcohol use. Alcohol use caused marked harm to others, which has not yet been researched sufficiently.
conclusionsResearch since 2010 confirms the importance of alcohol use as a risk factor for disease and injuries; for some health outcomes, more than one dimension of use needs to be considered. Epidemiological studies should include measurement of heavy drinking occasions in line with biological knowledge.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.