ArticlePituitary2017
Two-dimensional speckle tracking echocardiography demonstrates no effect of active acromegaly on left ventricular strain.
Article in Pituitary, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Myocardial Mechanics in Acromegaly: A Meta-Analysis of Echocardiographic Studies.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024Pooled it
- Article
- Diagnostic and prognostic value of myocardial work indices in evaluating cardiac function damage in active acromegaly patients.Endocrine connections · 2026Article
- Article
- Evaluation of the relation between subclinical systolic dysfunction defined by four-dimensional speckle-tracking echocardiography and growth differentiation factor-15 levels in patients with acromegaly.Hormones (Athens, Greece) · 2024Article
- Acromegaly in Speckle Tracking Echocardiography-A New Cardiac Hypertrophy Phenotype? Case Report and Review.Life (Basel, Switzerland) · 2024Review
- Acromegaly: The Relationship between Hemodynamic Profiles Assessed via Impedance Cardiography and Left Ventricular Systolic Function Assessed via Echocardiography.Journal of clinical medicine · 2024Article
- Myocardial, Valvular, and Vascular Structural and Functional Properties in Acromegaly.Journal of clinical medicine · 2023Review
- Effects of acromegaly treatment on left ventricular systolic function assessed by speckle tracking echocardiography in relation to sex differences: results from a prospective single center study.Frontiers in endocrinology · 2023Article
- Use of speckle tracking echocardiography in evaluating cardiac dysfunction in patients with acromegaly: an update.Frontiers in endocrinology · 2023Review
- Subclinical Left Atrial and Ventricular Dysfunction in Acromegaly Patients: A Speckle Tracking Echocardiography Study.Arquivos brasileiros de cardiologia · 2022Article
- Subclinical Ventricular Dysfunction in Long-Term Acromegaly Assessed by Speckle-Tracking Echocardiography.Frontiers in endocrinology · 2022Observational
- Advances in Research on the Cardiovascular Complications of Acromegaly.Frontiers in oncology · 2021Review
- Acromegaly and ultrasound: how, when and why?Journal of endocrinological investigation · 2020Review
- Left Heart Dysfunction in Acromegaly Revealed by Novel Echocardiographic Methods.Frontiers in endocrinology · 2020Article
- Effects of somatostatin analog treatment on cardiovascular parameters in patients with acromegaly: A systematic review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Review
- Heart in Acromegaly: The Echocardiographic Characteristics of Patients Diagnosed with Acromegaly in Various Stages of the Disease.International journal of endocrinology · 2018Article
- Determinants of morbidities and mortality in acromegaly.Archives of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpeckle tracking echocardiography (STE) allows for the study of myocardial strain (ε), a marker of early and subclinical ventricular systolic dysfunction. Cardiac disease may be present in patients with acromegaly; however, STE has never been used to evaluate these patients.
objectiveTo evaluate left ventricular (LV) global longitudinal strain in patients with active acromegaly with normal LV systolic function.
designCross-sectional clinical study.
methodsPatients with active acromegaly with no detectable heart disease and a control group were matched for age, gender, arterial hypertension and diabetes mellitus underwent STE. Global LV longitudinal ε (GLS), left ventricular mass index (LVMi), left ventricular ejection fraction (LVEF) and relative wall thickness (RWT) were obtained via two-dimensional (2D) echocardiography using STE.
resultsThirty-seven patients with active acromegaly (mean age 45.6 ± 13.8; 48.6% were males) and 48 controls were included. The mean GLS was not significantly different between the acromegaly group and the control group (in %, -20.1 ± 3.1 vs. -19.4 ± 2.2, p = 0.256). Mean LVMi was increased in the acromegaly group (in g/m
conclusionsAcromegaly patients, despite presenting with a higher LVMi when analyzed by 2D echocardiography, did not present with impairment in the strain when compared to a control group; this finding indicates a low chance of evolution to systolic dysfunction and agrees with recent studies that show a lower frequency of cardiac disease in these patients.
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