Evidence map›Paper›PMID 28220210›Full record

Trial reportNaunyn-Schmiedeberg's archives of pharmacology2017

Applicability of in vitro-in vivo translation of cathepsin K inhibition from animal species to human with the use of free-drug hypothesis.

Bennett Ma, Bin Luo, Danielle H Euler, Tara E Cusick, Gregg Wesolowski, Helmut Glantschnig, Le T Duong, Yangsi Ou, Steven S Carroll, Laura S Lubbers

Abstract readClinical Trial, Phase IRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Pharmacometrics and systems pharmacology for metabolic bone diseases.British journal of clinical pharmacology · 2019
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bennett MaDepartment of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, MSD, West Point, PA, 19486, USA. bennett_ma@merck.com.
Bin LuoDepartment of Pharmacology, MSD, West Point, PA, USA.
Danielle H EulerDepartment of Pharmacology, MSD, West Point, PA, USA.
Tara E CusickDepartment of Bone Biology, MSD, West Point, PA, USA.
Gregg WesolowskiDepartment of Bone Biology, MSD, West Point, PA, USA.
Helmut GlantschnigDepartment of Bone Biology, MSD, West Point, PA, USA.
Le T DuongDepartment of Bone Biology, MSD, West Point, PA, USA.
Yangsi OuDepartment of Pharmacology, MSD, West Point, PA, USA.
Steven S CarrollDepartment of Pharmacology, MSD, West Point, PA, USA.
Laura S LubbersDepartment of Pharmacology, MSD, West Point, PA, USA.
United States Military Academy · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The correlation of in vitro inhibition of cathepsin K (CatK) activity and in vivo suppression of collagen I biomarkers was examined with three selective CatK inhibitors to explore the potential translatability from animal species to human. These inhibitors exhibited good in vitro potencies toward recombinant CatK enzymes across species, with IC

Indexed as

AdolescentAdultAgedAnimalsBiomarkersBiphenyl CompoundsBlood ProteinsCathepsin KCollagen Type ICysteine Proteinase InhibitorsDogsFemaleHumansMacaca mulattaMaleMiddle Aged5,5-dichloro-N-(1-cyanocyclopropyl)-2-(4-(4-(methylsulfonyl)phenyl)-1-(2,2,2-trifluoroethyl)-1H-pyraazol-3-yl)cyclohexanecarboxamideBiomarkersBiphenyl CompoundsBlood ProteinsCathepsin KCollagen Type Icollagen type I trimeric cross-linked peptideCysteine Proteinase InhibitorsMK 0674odanacatibPeptidesPyrazolesSulfonesBone resorptionCathepsin KFree-drug hypothesisIn vitro-in vivo correlation

Identifiers

PMID28220210
OpenAlexW2589975641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.