SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2026Pooled it
- Evaluating agreement between individual nutrition randomised controlled trials and cohort studies - a meta-epidemiological study.BMC medicine · 2025Pooled it
- An Empirical Evaluation of the Impact Scenario of Pooling Bodies of Evidence from Randomized Controlled Trials and Cohort Studies in Nutrition Research.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis.Journal of bone and mineral metabolism · 2022Pooled it
- The relationship between serum vitamin D and fracture risk in the elderly: a meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Impact of Intravenous Iron Substitution on Serum Phosphate Levels and Bone Turnover Markers-An Open-Label Pilot Study.Nutrients · 2023Trial
- Impact of serum 25-hydroxyvitamin D levels on fragility fractures in patients undergoing chronic hemodialysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- The Impact of Serum 25-Hydroxyvitamin D on Bone Mineral Density at Different Skeletal Sites: A Multivariate Analysis Based on a UK Cohort Study.Food science & nutrition · 2026Article
- Comparison of vitamin D, parathyroid hormone (PTH), and bone metabolism markers in hip fracture patients by fracture type and control group.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Clinical Audit Determining Standard of Care for Musculoskeletal Health in Children With Spinal Cord Disorders.Topics in spinal cord injury rehabilitation · 2025Article
- Vitamin D and/or calcium to prevent fractures and falls: protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Vitamin D Deficiency Does Not Affect Cognition and Neurogenesis in Adult C57Bl/6 Mice.Nutrients · 2024Article
- Review
- Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment: based on the National Health Claims Database 2017-2019.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?Nutrients · 2023Review
- Calcifediol: Why, When, How Much?Pharmaceuticals (Basel, Switzerland) · 2023Review
- Characterization of Hip Fractures Among Adults With Schizophrenia in Ontario, Canada.JAMA network open · 2023Article
- Vitamin D Metabolites: Analytical Challenges and Clinical Relevance.Calcified tissue international · 2023Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this meta-analysis, we evaluated the association between serum 25-hydroxyvitamin D (25(OH) vitamin D) level and the risk of total fractures and hip fractures. Low serum 25(OH) vitamin D level is associated with an increased risk of total and hip fractures.
introductionData on the association between serum 25(OH) vitamin D level and the risk of fractures are conflicting. This study aimed to provide a summary of prospective cohort or nested case-control studies on the association between serum 25(OH) vitamin D level and the risk of total fractures and hip fractures.
methodsWe identified relevant studies by searching the PubMed, EMBASE, and OVID databases from their inception to June 1, 2016. We included published prospective cohort or nested case-control studies evaluating the associations of serum 25(OH) vitamin D level with the fracture risk. Two reviewers abstracted the data independently. Relative risks (RRs) with 95% confidence intervals (CIs) were derived throughout the whole analysis.
resultsSixteen prospective cohort studies and three nested case-control studies were included. We found that low serum 25(OH) vitamin D level was significantly associated with the risk of total fractures (RR 1.25, 95% CI 1.06-1.43; I
conclusionsOur study suggests that low serum 25(OH) vitamin D level is associated with increased risks of total and hip fractures. In the analyzed studies, the per SD decrease in serum 25(OH) vitamin D level was associated with the hip fracture risk but not with the total fracture risk.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.