ArticleMolecular psychiatry2017
Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents.Molecular psychiatry · 2025Pooled it
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- Molecular, Pathophysiological, and Clinical Aspects of Corticosteroid-Induced Neuropsychiatric Effects: From Bench to Bedside.Biomedicines · 2024Review
- The hypothalamic steroidogenic pathway mediates susceptibility to inflammation-evoked depression in female mice.Journal of neuroinflammation · 2023Article
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- Variables influencing conditioning-evoked hallucinations: overview and future applications.Psychological medicine · 2022Review
- A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria.Nature microbiology · 2022Article
- Targeted effects of ketamine on perceptual expectation during mediated learning in rats.Psychopharmacology · 2022Article
- Understanding Associative Learning Through Higher-Order Conditioning.Frontiers in behavioral neuroscience · 2022Review
- Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits.Frontiers in neuroscience · 2022Review
- CB1 Cannabinoid Receptor Signaling and Biased Signaling.Molecules (Basel, Switzerland) · 2021Review
- BK channel-forming slo1 proteins mediate the brain artery constriction evoked by the neurosteroid pregnenolone.Neuropharmacology · 2021Article
- Review of the Endocannabinoid System.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Review
- Training-Dependent Change in Content of Association in Appetitive Pavlovian Conditioning.Frontiers in behavioral neuroscience · 2021Article
- Neural Substrates of Incidental Associations and Mediated Learning: The Role of Cannabinoid Receptors.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Cannabis-induced acute psychotic-like states (CIAPS) represent a growing health issue, but their underlying neurobiological mechanisms are poorly understood. The use of antipsychotics and benzodiazepines against CIAPS is limited by side effects and/or by their ability to tackle only certain aspects of psychosis. Thus, safer wide-spectrum treatments are currently needed. Although the blockade of cannabinoid type-1 receptor (CB1) had been suggested as a therapeutical means against CIAPS, the use of orthosteric CB1 receptor full antagonists is strongly limited by undesired side effects and low efficacy. The neurosteroid pregnenolone has been recently shown to act as a potent endogenous allosteric signal-specific inhibitor of CB1 receptors. Thus, we tested in mice the potential therapeutic use of pregnenolone against acute psychotic-like effects of Δ
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.