ReviewJournal of the American Society of Nephrology : JASN2017
Novel Paradigms of Salt and Hypertension.
Review in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.Nature genetics · 2018Pooled it
- Glucocorticoids affect metabolic but not muscle microvascular insulin sensitivity following high versus low salt intake.JCI insight · 2020Trial
- Small RNA Sequencing of Human Urinary Extracellular Vesicles Reveals Association of High-Sodium Diet With Renal Proinflammatory Pathways.Journal of the American Heart Association · 2026Article
- The interface of aging and salt in driving salt-sensitive hypertension: a comparative study in aged and young rats.npj aging · 2026Article
- An Overview on Renal and Central Regulation of Blood Pressure by Neuropeptide FF and Its Receptors.International journal of molecular sciences · 2024Review
- Sodium, Interstitium, Lymphatics and Hypertension-A Tale of Hydraulics.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Role of thrombospondin-1 in high-salt-induced mesenteric artery endothelial impairment in rats.Acta pharmacologica Sinica · 2024Article
- Less sodium, more potassium, or both: population-wide strategies to prevent hypertension.American journal of physiology. Renal physiology · 2023Review
- Purinoceptor: a novel target for hypertension.Purinergic signalling · 2023Review
- Inverse Salt Sensitivity of Blood Pressure: Mechanisms and Potential Relevance for Prevention of Cardiovascular Disease.Current hypertension reports · 2022Review
- Does Excess Tissue Sodium Storage Regulate Blood Pressure?Current hypertension reports · 2022Review
- Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension.Clinical science (London, England : 1979) · 2022Article
- Synergistic Effect of Uroguanylin and DJournal of the American Heart Association · 2022Article
- Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.Arquivos brasileiros de cardiologia · 2021Article
- Impact ofMicroorganisms · 2021Review
- Salt-Sensitive Hypertension, Renal Injury, and Renal Vasodysfunction Associated With Dahl Salt-Sensitive Rats Are Abolished in Consomic SS.BN1 Rats.Journal of the American Heart Association · 2021Article
- Associations of urinary sodium excretion with central hemodynamics and changes in vascular structure and function at high altitude.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Capnometric feedback training decreases 24-h blood pressure in hypertensive postmenopausal women.BMC cardiovascular disorders · 2021Article
- Review
- The relationship between dietary patterns and overweight and obesity among adult in Jiangsu Province of China: a structural equation model.BMC public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Salt resistance/sensitivity refers specifically to the effect of dietary sodium chloride (salt) intake on BP. Increased dietary salt intake promotes an early and uniform expansion of extracellular fluid volume and increased cardiac output. To compensate for these hemodynamic changes and maintain constant BP in salt resistance, renal and peripheral vascular resistance falls and is associated with an increase in production of nitric oxide. In contrast, the decline in peripheral vascular resistance and the increase in nitric oxide are impaired or absent in salt sensitivity, promoting an increase in BP in these individuals. Endothelial dysfunction may pose a particularly significant risk factor in the development of salt sensitivity and subsequent hypertension. Vulnerable salt-sensitive populations may have in common underlying endothelial dysfunction due to genetic or environmental influences. These individuals may be very sensitive to the hemodynamic stress of increased effective blood volume, setting in motion untoward molecular and biochemical events that lead to overproduction of TGF-
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.