Evidence map›Paper›PMID 28219986›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Functional Analysis of the Transmembrane and Cytoplasmic Domains of Pcdh15a in Zebrafish Hair Cells.

Reo Maeda, Itallia V Pacentine, Timothy Erickson, Teresa Nicolson

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
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  5. Glycodiversification of gentamicins throughActa pharmaceutica Sinica. B · 2024
    Article
  6. Article
  7. Article
  8. TheInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Disruption ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  16. Temporal Vestibular Deficits inFrontiers in molecular neuroscience · 2020
    Article
  17. Review
  18. Article
  19. Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology.Journal of the Association for Research in Otolaryngology : JARO · 2019
    Review
  20. The Transfer Characteristics of Hair Cells Encoding Mechanical Stimuli in the Lateral Line of Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Reo MaedaOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239.
Itallia V PacentineOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239.ORCID 0000-0002-3041-7937
Timothy EricksonOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239.ORCID 0000-0002-0910-2535
Teresa NicolsonOregon Hearing Research Center and the Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 nicolson@ohsu.edu.ORCID 0000-0002-0873-1583
Oregon Health & Science University · US

Funding

Characterization of the Mechanotransduction complex in hair cellsR01DC013572 · NIDCD · STANFORD UNIVERSITY · PI NICOLSON, TERESA A · 2015 to 2019
$1.6M
Self-advocacy training for students with cochlear implants entering higher educationR44DC013503 · NIDCD · KDH RESEARCH AND COMMUNICATION, INC. · PI HOLTZ, KRISTEN D · 2018 to 2019
$1.2M
Self-advocacy training for students with cochlear implants entering collegeR43DC013503 · NIDCD · KDH RESEARCH AND COMMUNICATION, INC. · PI HOLTZ, KRISTEN D · 2013 to 2013
$189k
NIDCD NIH HHS R01 DC013572NIDCD NIH HHS R43 DC013503NIDCD NIH HHS R44 DC013503
6 · The paper itself

Abstract

Protocadherin 15 (PCDH15) is required for mechanotransduction in sensory hair cells as a component of the tip link. Isoforms of PCDH15 differ in their cytoplasmic domains (CD1, CD2, and CD3), but share the extracellular and transmembrane (TMD) domains, as well as an intracellular domain known as the common region (CR). In heterologous expression systems, both the TMD and CR of PCDH15 have been shown to interact with members of the mechanotransduction complex. The

Indexed as

AnimalsCadherin Related ProteinsCadherinsCell MembraneCells, CulturedCytoplasmHair Cells, AuditoryHair Cells, VestibularMechanotransduction, CellularProtein DomainsStructure-Activity RelationshipZebrafishZebrafish ProteinsCadherin Related ProteinsCadherinsCDHR15 protein, zebrafishZebrafish Proteinshair cellsmechanotransductionPCDH15tip linkszebrafish

Identifiers

PMID28219986
PMCPMC5373116
OpenAlexW2590807197

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.