Evidence map›Paper›PMID 28219981›Full record

ArticlePhysiological reports2017

The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation.

Elisabeth Schrumpf, Xiaojun Jiang, Sebastian Zeissig, Marion J Pollheimer, Jarl Andreas Anmarkrud, Corey Tan, Mark A Exley, Tom H Karlsen, Richard S Blumberg, Espen Melum

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Cholangiocyte pathobiology.Nature reviews. Gastroenterology & hepatology · 2019
    Review
  4. Review
  5. The IBD and PSC Phenotypes of PSC-IBD.Current gastroenterology reports · 2018
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 5 countries.

Elisabeth SchrumpfNorwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Xiaojun JiangNorwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Sebastian ZeissigDepartment of Medicine 1, University Medical Center Dresden Technical University Dresden, Dresden, Germany.
Marion J PollheimerDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Research Unit for Experimental and Molecular Hepatology, Graz, Austria.
Jarl Andreas AnmarkrudNorwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Corey TanNorwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Mark A ExleyManchester Collaborative Centre for Inflammation Research (MCCIR), Faculty of Medical & Human Sciences, University of Manchester, Manchester, United Kingdom.
Tom H KarlsenNorwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Richard S BlumbergDivision of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Espen MelumNorwegian PSC Research Center, Division of Surgery, Inflammatory Diseases and Transplantation Oslo University Hospital, Rikshospitalet, Oslo, Norway espen.melum@medisin.uio.no.
Oslo University Hospital · NOBrigham and Women's Hospital · USUniversity of Oslo · NOMedical University of Graz · ATTU Dresden · DE

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
MOLECULAR CHARACTERIZATION OF MUCOSAL LYMPHOCYTESR01DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 1992 to 2026
$10.4M
NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK044319
6 · The paper itself

Abstract

Natural killer T (NKT) cells are activated by lipid antigens presented by CD1d molecules and represent a major lymphocyte subset of the liver. NODc3c4 mice spontaneously develop biliary inflammation in extra- and intrahepatic bile ducts. We demonstrated by flow cytometry that invariant NKT (iNKT) cells were more abundant in the thymus, spleen, and liver of NODc3c4 mice compared to NOD mice. iNKT cells in NODc3c4 mice displayed an activated phenotype. Further, NOD and NOD

Indexed as

AnimalsAntigens, CD1dBile Duct DiseasesDisease Models, AnimalGalactosylceramidesInflammationLiverMiceMice, KnockoutNatural Killer T-CellsSpleenThymus Glandalpha-galactosylceramideAntigens, CD1dGalactosylceramidesCholestasisNKTNOD.c3c4PBCPSC

Identifiers

PMID28219981
PMCPMC5328767
OpenAlexW2589241776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.