Evidence map›Paper›PMID 28219980›Full record

ArticlePhysiological reports2017

Activation of neuronal endothelin B receptors mediates pressor response through alpha-1 adrenergic receptors.

Bryan K Becker, Joshua S Speed, Mackenzie Powell, David M Pollock

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. What Are the Neurotoxins in Hemotoxic Snake Venoms?International journal of molecular sciences · 2023
    Review
  3. Article
  4. Endothelin-1 in the pathophysiology of obesity and insulin resistance.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Renal denervation attenuates hypertension but not salt sensitivity in ETAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bryan K BeckerDivision of Nephrology, Department of Medicine, Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Joshua S SpeedDivision of Nephrology, Department of Medicine, Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Mackenzie PowellDivision of Nephrology, Department of Medicine, Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
David M PollockDivision of Nephrology, Department of Medicine, Cardio-Renal Physiology and Medicine, University of Alabama at Birmingham, Birmingham, Alabama davidpollock@uabmc.edu.
Pediatric Nephrology of Alabama · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANANDA BASU · 2013 to 2026
$19.5M
MECHANISMS OF HYPERTENSION AND CARDIOVASCULAR DISEASEST32HL007457 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Martin E Young · 1985 to 2026
$8.6M
Endothelin - Mechanisms in Hypertension and ObesityK99HL127178 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SPEED, JOSHUA S · 2016 to 2017
$308k
NHLBI NIH HHS K99 HL127178NHLBI NIH HHS T32 HL007457NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

Abnormalities in activity of the endothelin (ET) system have been widely reported in a number of cardiovascular disease states such as hypertension and heart failure. Although the vascular responses to ET are well established, the interaction between ET and other important modulators of blood pressure, such as the sympathetic nervous system, are less understood. Previous reports implicate ET signaling through ET type B (ET

Indexed as

Adrenergic alpha-1 Receptor AntagonistsAdrenergic beta-AntagonistsAnimalsBlood PressureDose-Response Relationship, DrugHeart RateNeuronsPrazosinPropranololRatsRats, TransgenicReceptor, Endothelin BReceptors, Adrenergic, alpha-1Sympathetic Nervous SystemVasoconstrictor AgentsViper VenomsAdrenergic alpha-1 Receptor AntagonistsAdrenergic beta-AntagonistsPrazosinPropranololReceptor, Endothelin BReceptors, Adrenergic, alpha-1sarafotoxins s6Vasoconstrictor AgentsViper VenomsBlood pressurehypertensionsympathetic nerves

Identifiers

PMID28219980
PMCPMC5328762
OpenAlexW2590384782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.