Trial reportJournal of the American Heart Association2017
Twenty-Five-Year Alcohol Consumption Trajectories and Their Association With Arterial Aging: A Prospective Cohort Study.
Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02663791 (Alcohol Consumption and Arterial Stiffness), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alcohol Consumption and Arterial Stiffness: A Longitudinal Study of Pulse Wave Velocity in the Whitehall II Cohort
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between Alcohol Intake and Arterial Stiffness in Healthy Adults: A Systematic Review.Nutrients · 2022Pooled it
- Association of longitudinal alcohol consumption trajectories with coronary heart disease: a meta-analysis of six cohort studies using individual participant data.BMC medicine · 2018Pooled it
- Article
- Prevalence of alcohol use disorder and its association with disease severity in symptomatic peripheral arterial disease.Scientific reports · 2026Observational
- Alcohol Consumption Patterns and Peripheral Arterial Stiffness in Young Adults: Sex-Specific Findings from the EVA-Adic Study.Nutrients · 2026Observational
- Heavy alcohol consumption attenuates human mesenteric artery responsiveness to sigma receptor-1 ligands.American journal of physiology. Heart and circulatory physiology · 2026Article
- Article
- Interaction effects of alcohol consumption and dizziness/vertigo on fall risk in psychiatric Inpatients: a cross-sectional study.Frontiers in psychiatry · 2025Article
- The Relationship between Healthy Vascular Aging with the Mediterranean Diet and Other Lifestyles in the Spanish Population: The EVA Study.Nutrients · 2024Article
- Relationship between addictions and obesity, physical activity and vascular aging in young adults (EVA-Adic study): a research protocol of a cross-sectional study.Frontiers in public health · 2024Article
- Observational
- Association between tobacco smoking and alcohol consumption with arterial stiffness.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The Potential for Prevention Science in Middle and Late Adulthood: a Commentary on the Special Issue of Prevention Science.Prevention science : the official journal of the Society for Prevention Research · 2023Review
- Predictors of beverage-specific, alcohol consumption trajectories: A Swedish population-based cohort study.Nordisk alkohol- & narkotikatidskrift : NAT · 2023Article
- Longitudinal Associations between Alcohol Intake and Arterial Stiffness, Pressure Wave Reflection, and Inflammation.Journal of atherosclerosis and thrombosis · 2023Observational
- Arterial stiffness nomogram identification by cluster analysis: A new approach of vascular phenotype modeling.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Alcohol Consumption: A New Risk Factor for Arterial Stiffness?Cardiovascular toxicology · 2022Review
- Association between Lifetime Tobacco Use and Alcohol Consumption Trajectories and Cardiovascular and Chronic Respiratory Diseases among Older People.International journal of environmental research and public health · 2021Article
- Lifetime employment, tobacco use, and alcohol consumption trajectories and cardiovascular diseases in old age.SSM - population health · 2021Article
- Quality of Beverage Intake and Cardiometabolic and Kidney Outcomes: Insights From the STANISLAS Cohort.Frontiers in nutrition · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundEmerging evidence suggests that arterial stiffness, an important marker of cardiovascular health, is associated with alcohol consumption. However, the role of longer-term consumption patterns in the progression of arterial stiffness over time remains unclear. A longitudinal cohort design was used to evaluate the association between alcohol consumption over 25 years and subsequent changes in arterial stiffness. METHODS AND
resultsData (N=3869; 73% male) were drawn from the Whitehall II cohort study of British civil servants, in which participants completed repeat pulse wave velocity assessments of arterial stiffness across a 4- to 5-year interval. Repeated alcohol intake measurements were used to categorize participants into alcohol consumer types, accounting for longitudinal variability in consumption. Sex-stratified linear mixed-effects modeling was used to investigate whether drinker types differed in their relationship to pulse wave velocity and its progression over time. Males with consistent long-term heavy intake >112 g of ethanol/week had significantly higher baseline pulse wave velocity (b=0.26 m/s;
conclusionsThis work demonstrates that consistently heavy alcohol consumption is associated with higher cardiovascular risk, especially among males, and also provides new insights into the potential impact of changes in drinking levels over time. It discusses the additional insights possible when capturing longitudinal consumption patterns in lieu of reliance on recent intake alone. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02663791.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.