Evidence map›Paper›PMID 28219920›Full record

Trial reportJournal of the American Heart Association2017

Impact of Coronary Artery Disease Severity Assessed With the SYNTAX Score on Outcomes Following Transcatheter Aortic Valve Replacement.

Jean-Michel Paradis, Jonathon M White, Philippe Généreux, Marina Urena, Darshan Doshi, Tamim Nazif, Rebecca Hahn, Isaac George, Omar Khalique, Kishore Harjai and 9 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  19. TAVI imaging: over the echocardiography.La Radiologia medica · 2020
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Jean-Michel ParadisQuebec Heart and Lung Institute, Quebec, Canada.
Jonathon M WhiteColumbia University Medical Center, New-York, NY.
Philippe GénéreuxCardiovascular Research Foundation, New-York, NY.
Marina UrenaQuebec Heart and Lung Institute, Quebec, Canada.
Darshan DoshiColumbia University Medical Center, New-York, NY.
Tamim NazifCardiovascular Research Foundation, New-York, NY.
Rebecca HahnCardiovascular Research Foundation, New-York, NY.
Isaac GeorgeColumbia University Medical Center, New-York, NY.
Omar KhaliqueColumbia University Medical Center, New-York, NY.
Kishore HarjaiColumbia University Medical Center, New-York, NY.
Laura LasalleCardiovascular Research Foundation, New-York, NY.
Benoit M LabbéQuebec Heart and Lung Institute, Quebec, Canada.
Robert DeLarochellièreQuebec Heart and Lung Institute, Quebec, Canada.
Daniel DoyleQuebec Heart and Lung Institute, Quebec, Canada.
Éric DumontQuebec Heart and Lung Institute, Quebec, Canada.
Siamak MohammadiQuebec Heart and Lung Institute, Quebec, Canada.
Martin B LeonCardiovascular Research Foundation, New-York, NY.
Josep Rodés-CabauQuebec Heart and Lung Institute, Quebec, Canada.
Susheel KodaliCardiovascular Research Foundation, New-York, NY sk2427@cumc.columbia.edu.
Columbia University Irving Medical Center · USMontreal Heart Institute · CACardiovascular Research Foundation · USMorristown Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. METHODS AND

resultsA total of 377 patients who underwent TAVR in 2 high-volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis. Patients were stratified into 4 groups: (1) no CAD (SS=0); (2) low SS (SS between 1 and 22); (3) intermediate SS (SS between 23 and 32); and (4) high SS (SS ≥33). Patients who had undergone percutaneous coronary intervention within 6 months prior to TAVR were separated into 2 categories based on their residual SS (<8 and ≥8). Patients with previous coronary artery bypass grafting (CABG) were divided into 2 groups: (1) low CABG SS and (2) high CABG SS. The primary end point was a composite of all-cause mortality, myocardial infarction, and stroke. At 30 days and 1 year, both the presence and the severity of CAD had no impact on the rate of the combined primary end point and on all-cause mortality, cardiovascular mortality, and myocardial infarction. Patients with less complete revascularization (residual SS ≥8 versus residual SS <8 and low CABG SS versus high CABG SS, had similar rates of the combined primary end point, all-cause mortality, cardiovascular mortality, MI, and stroke, at both 30 days and 1 year.

conclusionsIn our core laboratory-validated study, neither the severity of CAD nor completeness of revascularization after percutaneous coronary intervention or CABG were associated with clinical outcomes after TAVR, at both 30 days and 1 year.

Indexed as

Percutaneous Coronary InterventionTranscatheter Aortic Valve ReplacementAged, 80 and overAortic Valve StenosisCause of DeathCoronary AngiographyCoronary Artery DiseaseEchocardiographyFemaleFollow-Up StudiesHumansMaleNorth AmericaRetrospective StudiesSeverity of Illness IndexSurvival Rateaortic stenosiscoronary artery diseaseSYNTAX scoretranscatheter aortic valve replacement

Identifiers

PMID28219920
PMCPMC5523783
OpenAlexW2590885247

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.