ArticleJournal of the American Heart Association2017
Dickkopf-3 Ablation Attenuates the Development of Atherosclerosis in ApoE-Deficient Mice.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05828368 (Determination of Dickkopf-3 rs11544814 and Complement Factor H rs10737680 Genetic Polymorphism and Change in Their Protein Levels Before and After Non Surgical Periodontal Therapy in Periodontitis Patients With and Without Coronary Artery Disease), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determination of Dickkopf-3 rs11544814 and Complement Factor H rs10737680 Genetic Polymorphism and Change in Their Protein Levels Before and After Non Surgical Periodontal Therapy in Periodontitis Patients With and Without Coronary Artery Disease
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Recent insights into the pathophysiology and implications for surgery in atherosclerosis.Journal of cardiothoracic surgery · 2025Review
- Mechanism of DKK3 protecting brain tissues in ischemic stroke by regulating LGI1 expression and activity.European journal of medical research · 2025Article
- Roles of myokines in osteoporosis under physiological and diabetic conditions.Frontiers in endocrinology · 2025Review
- Gene and protein profiling of Dickkopf-3 and complement factor H in periodontitis and coronary artery disease.Frontiers in dental medicine · 2025Article
- Elevated Dickkopf 3 Promotes Abdominal Aortic Aneurysm Formation via Modulated Phenotype Switch of Vascular Smooth Muscle Cells.Research (Washington, D.C.) · 2025Article
- Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis.Translational vision science & technology · 2024Article
- Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis.Circulation research · 2024Article
- Patterns of Dickkopf-3 Serum and Urine Levels at Different Stages of Chronic Kidney Disease.Journal of clinical medicine · 2023Article
- Review
- The elevation of miR-185-5p alleviates high-fat diet-induced atherosclerosis and lipid accumulationAging · 2022Article
- Inhibition of microRNA-494-3p activates Wnt signaling and reduces proinflammatory macrophage polarization in atherosclerosis.Molecular therapy. Nucleic acids · 2021Article
- The emerging plasma biomarker Dickkopf-3 (DKK3) and its association with renal and cardiovascular disease in the general population.Scientific reports · 2021Article
- miR-25-3p protects renal tubular epithelial cells from apoptosis induced by renal IRI by targeting DKK3.Open life sciences · 2021Article
- The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease.Frontiers in cardiovascular medicine · 2021Article
- Molecular Biology of Atherosclerotic Ischemic Strokes.International journal of molecular sciences · 2020Review
- The role of Wnt signalling in development of coronary artery disease and its risk factors.Open biology · 2020Review
- Serum dickkopf-3 is associated with death and vascular events after ischemic stroke: an observational study from CATIS.Journal of neuroinflammation · 2020Observational
- Oxidized Low-Density Lipoprotein Induces WNT5A Signaling Activation in THP-1 Derived Macrophages and a Human Aortic Vascular Smooth Muscle Cell Line.Frontiers in cardiovascular medicine · 2020Article
- Cytoskeleton-Associated Protein 4, a Promising Biomarker for Tumor Diagnosis and Therapy.Frontiers in molecular biosciences · 2020Review
- Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis.Circulation research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDickkopf-3 (DKK3) is a negative regulator of the Wnt/β-catenin signaling pathway, which is involved in inflammation. However, little is known about the relationship between DKK3 expression and the progression of atherosclerosis. The aim of the present study was to define the role of DKK3 and its potential mechanism in the development of atherosclerosis. METHODS AND
resultsImmunofluorescence analysis showed that DKK3 was strongly expressed in macrophages of atherosclerotic plaques from patients with coronary heart disease and in hyperlipidemic mice. The expression level was significantly increased in atherogenesis. DKK3
conclusionsDKK3 expression in macrophages is involved in the pathogenesis of atherosclerosis through modulation of inflammation and inactivation of the Wnt/β-catenin pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.