ArticleJournal of immunology (Baltimore, Md. : 1950)2017
CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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0cells of the map it votes in
15citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
What it found
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- A MIF-p38-GSDMD inflammatory loop in keratinocytes underlies UVB-induced cutaneous lupus.Cell death & disease · 2026Article
- Spatial transcriptomic profiling identifies lacrimal-gland-epithelial cell-driven mechanisms underlying autoimmunity in Sjögren's disease.Frontiers in immunology · 2026Article
- Spatial transcriptomic profiling identifies lacrimal gland epithelial cell-driven mechanisms underlying autoimmunity in Sjögren's disease.bioRxiv : the preprint server for biology · 2025Article
- Single-cell multi-omics analysis revealed the expansion of age-associated B cells in the pancreas of type 1 autoimmune pancreatitis patients.Genome medicine · 2025Article
- Macrophage migration inhibitory factor: Exploring physiological roles and comparing health benefits against oncogenic and autoimmune risks (Review).International journal of molecular medicine · 2025Review
- Article
- Article
- A Novel Murine Model for Lupus-Like Ocular Chronic Graft-Versus-Host Disease.Investigative ophthalmology & visual science · 2024Article
- Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis.Frontiers in immunology · 2023Article
- T cell help in the autoreactive germinal center.Scandinavian journal of immunology · 2022Review
- Lupus Susceptibility Loci Predispose Mice to Clonal Lymphocytic Responses and Myeloid Expansion.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation.International journal of molecular sciences · 2022Review
- Proteomic Analysis Revealed the Characteristics of Key Proteins Involved in the Regulation of Inflammatory Response, Leukocyte Transendothelial Migration, Phagocytosis, and Immune Process during Early Lung Blast Injury.Oxidative medicine and cellular longevity · 2021Article
- Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.Respiratory research · 2020Review
- Role of MIF Cytokine/CD74 Receptor Pathway in Protecting Against Injury and Promoting Repair.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Yi ZhouDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.ORCID 0000-0002-3425-2404
Huimei ChenDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Li LiuDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-7649-8904
Xueqing YuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China; gshi@rics.bwh.harvard.edu yuxq@mail.sysu.edu.cn.
Galina K SukhovaDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Min YangDepartment of Rheumatology, Nan Fang Hospital, Southern Medical University, Guangzhou 510515, China.
Lijun ZhangDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Vasileios C KyttarisDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; and.
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; and.ORCID 0000-0001-9589-2360
Isaac E StillmanDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215.ORCID 0000-0002-4224-5060
Takaharu IchimuraDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-3106-5224
Joseph V BonventreDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-1502-502X
Guo-Ping ShiDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; gshi@rics.bwh.harvard.edu yuxq@mail.sysu.edu.cn.
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USSouthern Medical University · CNSun Yat-sen University · CN
Funding
KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIRR01DK072381 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 2005 to 2025
$8.6MLYMPHOCYTE SIGNALING DEFECTS IN PATIENTS WITH LUPUSR01AI042269 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI TSOKOS, GEORGE C · 1998 to 2017
$6.8MRole of mast cells in obesityR01HL060942 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SHI, GUO-PING · 1999 to 2019
$5.6MMolecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0MRole of Mast Cells in AtherosclerosisR01HL081090 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2007 to 2015
$3.3MKidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUH3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2019 to 2021
$3.3MInflammatory Mechanisms of AtherosclerosisR01HL034636 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LIBBY, PETER · 1985 to 2006
$1.9MRole of a novel IL18 binding protein in atherosclerosisR01HL123568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2015 to 2018
$1.7MThe IL-18/Caspase-1 cascade in atherosclerosisR01HL067283 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2003 to 2006
$1.6MCONTROL OF GROWTH OF VASCULAR WALL CELLSR37HL034636 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 1993 to 2002
$1.2MNCATS NIH HHS UH3 TR002155NHLBI NIH HHS R01 HL034636NHLBI NIH HHS R01 HL060942NHLBI NIH HHS R01 HL067283NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL081090NHLBI NIH HHS R01 HL123568NHLBI NIH HHS R37 HL034636NIAID NIH HHS R01 AI042269NIDDK NIH HHS R01 DK072381
Abstract
CD74 mediates MHC class-II antigenic peptide loading and presentation and plays an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. C57BL/6
Indexed as
AnimalsAntigen PresentationAntigen-Presenting CellsAntigens, Differentiation, B-LymphocyteAutoimmune DiseasesAutoimmunityBlotting, WesternDisease Models, AnimalEnzyme-Linked Immunosorbent AssayEpithelial CellsGraft vs Host DiseaseHistocompatibility Antigens Class IIImmunohistochemistryKidney TubulesLupus NephritisLymphocyte ActivationAntigens, Differentiation, B-LymphocyteHistocompatibility Antigens Class IIinvariant chain
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.