Evidence map›Paper›PMID 28219886›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow-Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice.

Sun-Sang J Sung, Yan Ge, Chao Dai, Hongyang Wang, Shu Man Fu, Rahul Sharma, Young S Hahn, Jing Yu, Thu H Le, Mark D Okusa and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Roles of macrophages in lupus nephritis.Frontiers in pharmacology · 2024
    Review
  4. Article
  5. Article
  6. The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Macrophage Dysfunction in Autoimmune Rheumatic Diseases and Atherosclerosis.International journal of molecular sciences · 2022
    Review
  10. Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy.The spine journal : official journal of the North American Spine Society · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. M2b macrophage polarization and its roles in diseases.Journal of leukocyte biology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sun-Sang J SungDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908; sjs5c@Virginia.edu.ORCID 0000-0001-5432-691X
Yan GeDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.
Chao DaiDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.
Hongyang WangDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.
Shu Man FuDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.ORCID 0000-0001-5158-3494
Rahul SharmaDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.ORCID 0000-0002-3115-3523
Young S HahnDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908; and.ORCID 0000-0002-2698-9844
Jing YuDepartment of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, VA 22908.
Thu H LeDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.ORCID 0000-0002-1906-064X
Mark D OkusaDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.
Warren K BoltonDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.ORCID 0000-0003-0589-6849
Jessica R LawlerDepartment of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908.ORCID 0000-0002-3350-6599
University of Virginia · US

Funding

Cellular and Genetic Basis of Systemic LupusR01AR047988 · NIAMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI FU, SHU MAN · 2001 to 2020
$8.4M
Regulation of CD8+ T cell responses via liver NK-DC crosstalkU19AI083024 · NIAID · UNIVERSITY OF VIRGINIA · PI BRACIALE, THOMAS J · 2009 to 2013
$8.1M
SPECIALIZED CENTER OF RESEARCH ON SYSTEMIC LUPUS ERYTHEMP50AR045222 · NIAMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI FU, SHU MAN · 1998 to 2006
$7.9M
Leukocyte Trafficking in Acute Renal FailureR01DK062324 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI OKUSA, MARK DOUGLAS · 2003 to 2016
$4.4M
Ultrasound for Non-Invasive Prevention of Acute Kidney InjuryR01DK105133 · NIDDK · UNIVERSITY OF VIRGINIA · PI OKUSA, MARK DOUGLAS · 2015 to 2019
$2.4M
Molecular and Cellular Regulation of Mammalian Renal Medulla DevelopmentR01DK085080 · NIDDK · UNIVERSITY OF VIRGINIA · PI YU, JING · 2010 to 2014
$1.7M
GSTM1, APOL1, and their joint contribution to severity of hypertension and chronic kidney diseaseR01DK094907 · NIDDK · UNIVERSITY OF VIRGINIA · PI LE, THU H., MYCHALECKYJ, JOSYF · 2012 to 2021
$1.7M
Targeting Treg for Therapy of Lupus GlomerulonephritisR01DK105833 · NIDDK · UNIVERSITY OF VIRGINIA · PI FU, SHU MAN, SHARMA, RAHUL · 2016 to 2019
$1.4M
Experimental Autoimmune Nephritis: Epitope Spreading in Pathogenesis and ControlR01DK076095 · NIDDK · UNIVERSITY OF VIRGINIA · PI BOLTON, WARREN KLINE · 2008 to 2011
$1.3M
NIAID NIH HHS U19 AI083024NIAMS NIH HHS P50 AR045222NIAMS NIH HHS R01 AR047988NIDDK NIH HHS R01 DK062324NIDDK NIH HHS R01 DK076095NIDDK NIH HHS R01 DK085080NIDDK NIH HHS R01 DK094907NIDDK NIH HHS R01 DK105133NIDDK NIH HHS R01 DK105833
6 · The paper itself

Abstract

Glomerular damage mediated by glomerulus-infiltrating myeloid-derived cells is a key pathogenic event in lupus nephritis (LN), but the process is poorly understood. Confocal microscopy of kidney sections and flow cytometry analysis of glomerular cells from magnetic bead-purified glomeruli have identified glomerulus-infiltrating leukocyte populations in NZM2328 (NZM) lupus-prone mice with spontaneous chronic glomerulonephritis (GN) and anti-glomerular basement membrane-induced nephritis. The occurrence of a major glomerulus-infiltrating CD11b

Indexed as

AnimalsB7-H1 AntigenBone Marrow CellsCell SeparationDisease Models, AnimalFemaleFlow CytometryKidney GlomerulusKruppel-Like Factor 4Lupus NephritisMacrophage-1 AntigenMacrophagesMiceMice, Mutant StrainsMicroscopy, ConfocalReal-Time Polymerase Chain ReactionB7-H1 AntigenCd274 protein, mouseKlf4 protein, mouseKruppel-Like Factor 4Macrophage-1 Antigen

Identifiers

PMID28219886
PMCPMC5360484
OpenAlexW2589202948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.