Evidence map›Paper›PMID 28219774›Full record

ArticleNeuroImage2019

Dynamic causal modelling revisited.

K J Friston, Katrin H Preller, Chris Mathys, Hayriye Cagnan, Jakob Heinzle, Adeel Razi, Peter Zeidman

Open access · hybridAbstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 2 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 2 syntheses or guidelines pooled it, 290 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026
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  13. A Large-scale Neural Model Inversion Framework for Effective Connectivity Estimation.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
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  19. Five Fristonian Formulae.Entropy (Basel, Switzerland) · 2025
    Article
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

K J FristonThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom. Electronic address: k.friston@ucl.ac.uk.
Katrin H PrellerThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom; Neuropsychopharmacology and Brain Imaging, Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital for Psychiatry Zurich, 8032 Zurich, Switzerland. Electronic address: preller@bli.uzh.ch.
Chris MathysThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, United Kingdom. Electronic address: c.mathys@ucl.ac.uk.
Hayriye CagnanThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom; MRC Brain Network Dynamics Unit (BNDU), Department of Pharmacology and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. Electronic address: hayriye.cagnan@ndcn.ox.ac.uk.
Jakob HeinzleThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom; Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, 8032 Zürich, Switzerland. Electronic address: heinzle@biomed.ee.ethz.ch.
Adeel RaziThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom; Department of Electronic Engineering, NED University of Engineering and Technology, Karachi, Pakistan. Electronic address: a.razi@ucl.ac.uk.
Peter ZeidmanThe Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom. Electronic address: peter.zeidman@ucl.ac.uk.
Wellcome Centre for Human Neuroimaging · GBUniversity College London · GBInstitute for Biomedical Engineering · CHUniversity of Oxford · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

This paper revisits the dynamic causal modelling of fMRI timeseries by replacing the usual (Taylor) approximation to neuronal dynamics with a neural mass model of the canonical microcircuit. This provides a generative or dynamic causal model of laminar specific responses that can generate haemodynamic and electrophysiological measurements. In principle, this allows the fusion of haemodynamic and (event related or induced) electrophysiological responses. Furthermore, it enables Bayesian model comparison of competing hypotheses about physiologically plausible synaptic effects; for example, does attentional modulation act on superficial or deep pyramidal cells - or both? In this technical note, we describe the resulting dynamic causal model and provide an illustrative application to the attention to visual motion dataset used in previous papers. Our focus here is on how to answer long-standing questions in fMRI; for example, do haemodynamic responses reflect extrinsic (afferent) input from distant cortical regions, or do they reflect intrinsic (recurrent) neuronal activity? To what extent do inhibitory interneurons contribute to neurovascular coupling? What is the relationship between haemodynamic responses and the frequency of induced neuronal activity? This paper does not pretend to answer these questions; rather it shows how they can be addressed using neural mass models of fMRI timeseries.

Indexed as

Models, BiologicalAdultBrainElectroencephalographyFunctional NeuroimagingHemodynamicsHumansMagnetic Resonance ImagingMotion PerceptionNerve NetNeurovascular CouplingBayesianDynamic causal modellingEffective connectivityHaemodynamic modelsNeural mass models

Identifiers

PMID28219774
PMCPMC6693530
OpenAlexW2588388246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.