Evidence map›Paper›PMID 28219659›Full record

ArticleMolecular and cellular neurosciences2017

Dementia-like pathology in type-2 diabetes: A novel microRNA mechanism.

Anuradha Kalani, Pankaj Chaturvedi, Claudio Maldonado, Philip Bauer, Irving G Joshua, Suresh C Tyagi, Neetu Tyagi

Open access · greenAbstract read
In one paragraph

Article in Molecular and cellular neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  6. Diabetes complications and extracellular vesicle therapy.Reviews in endocrine & metabolic disorders · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anuradha KalaniDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA. Electronic address: a0kala02@louisville.edu.
Pankaj ChaturvediDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Claudio MaldonadoDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA; Department of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Philip BauerDepartment of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Irving G JoshuaDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Suresh C TyagiDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
Neetu TyagiDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.
University of Louisville · US

Funding

Reversing diabetic muscle myopathy by exercise and exosomesR01HL074185 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, SURESH C. · 2003 to 2018
$5.7M
Mechanisms of Mitochondrial Dysfunction in Brain VasculatureR01HL107640 · NHLBI · UNIVERSITY OF LOUISVILLE · PI TYAGI, NEETU · 2012 to 2016
$1.8M
NHLBI NIH HHS R01 HL074185NHLBI NIH HHS R01 HL107640
6 · The paper itself

Abstract

Although type-2 diabetes (T2D) has been reported to increase the risk of cognitive dysfunction and dementia, the underlying mechanisms remain unclear. Dementia-like pathology is attributed to the accumulation of cellular prion protein (PrP

Indexed as

AnimalsBrainDementiaDiabetes Mellitus, Type 2Disease Models, AnimalEndothelial Growth FactorsGene Expression RegulationGlycogen Synthase Kinase 3MaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutMicroRNAsMicrotubule-Associated ProteinsPrion ProteinsEndothelial Growth FactorsGlycogen Synthase Kinase 3MicroRNAsMicrotubule-Associated ProteinsMirn146 microRNA, mousePrion ProteinsReceptors, LeptinRNA, Messengertau ProteinsCellular prion proteinDementiaDiabetesMemorymicroRNA

Identifiers

PMID28219659
PMCPMC5432966
OpenAlexW2590258507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.