Evidence map›Paper›PMID 28219463›Full record

ArticleEpidemiology and infection2017

Factors associated with persistent colonisation with methicillin-resistant Staphylococcus aureus.

V C Cluzet, J S Gerber, I Nachamkin, S E Coffin, M F Davis, K G Julian, T E Zaoutis, J P Metlay, D R Linkin, P Tolomeo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Risk of meticillin resistantBMJ (Clinical research ed.) · 2018
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

V C CluzetDivision of Infectious Diseases,Department of Medicine,Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
J S GerberCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.ORCID 0000-0002-3076-3186
I NachamkinDepartment of Pathology and Laboratory Medicine,Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
S E CoffinCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
M F DavisDepartment of Environmental Health Sciences,Johns Hopkins Bloomberg School of Public Health,Baltimore, MD,USA.
K G JulianDivision of Infectious Diseases,Penn State Hershey Medical Center,Hershey,USA.
T E ZaoutisCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
J P MetlayDepartment of Medicine,Massachusetts General Hospital, Harvard Medical School,Boston,USA.
D R LinkinDivision of Infectious Diseases,Department of Medicine,Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
P TolomeoCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
J A WiseCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
W B BilkerCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
B HuDepartment of Pathology and Laboratory Medicine,Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
E LautenbachDivision of Infectious Diseases,Department of Medicine,Perelman School of Medicine, University of Pennsylvania,Philadelphia,USA.
CDC PREVENTION EPICENTERS PROGRAM

Funding

Mentoring and patient-oriented research in antimicrobial resistanceK24AI080942 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2009 to 2013
$853k
ACL HHS U54CK000163NCEZID CDC HHS U54 CK000163NIAID NIH HHS K24 AI080942
6 · The paper itself

Abstract

We conducted a prospective cohort study between 1 January 2010 and 31 December 2012 at five adult and paediatric academic medical centres to identify factors associated with persistent methicillin-resistant Staphylococcus aureus (MRSA) colonisation. Adults and children presenting to ambulatory settings with a MRSA skin and soft tissue infection (i.e. index cases), along with household members, performed self-sampling for MRSA colonisation every 2 weeks for 6 months. Clearance of colonisation was defined as two consecutive negative sampling periods. Subjects without clearance by the end of the study were considered persistently colonised and compared with those who cleared colonisation. Of 243 index cases, 48 (19·8%) had persistent colonisation and 110 (45·3%) cleared colonisation without recurrence. Persistent colonisation was associated with white race (odds ratio (OR), 4·90; 95% confidence interval (CI), 1·38-17·40), prior MRSA infection (OR 3·59; 95% CI 1·05-12·35), colonisation of multiple sites (OR 32·7; 95% CI 6·7-159·3). Conversely, subjects with persistent colonisation were less likely to have been treated with clindamycin (OR 0·28; 95% CI 0·08-0·99). Colonisation at multiple sites is a risk factor for persistent colonisation and may require more targeted decolonisation efforts. The specific effect of clindamycin on MRSA colonisation needs to be elucidated.

Indexed as

AdolescentAdultAgedAnti-Bacterial AgentsChildChild, PreschoolClindamycinFemaleHumansInfantInfant, NewbornMaleMethicillinMethicillin-Resistant Staphylococcus aureusMiddle AgedPennsylvaniaAnti-Bacterial AgentsClindamycinMethicillinMethicillin-resistant Staphylococcus aureus (MRSA)MRSA colonisationMRSA skin and soft tissue infectionspersistent MRSA colonisation

Identifiers

PMID28219463
PMCPMC9203296

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.