ArticleCritical care (London, England)2017
The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study.
Article in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative oral practices and incidence of postoperative complications in hospital medical-surgical procedures: A meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2023Pooled it
- Association of Obesity With Septic Complications After Major Abdominal Surgery: A Secondary Analysis of the RELIEF Randomized Clinical Trial.JAMA network open · 2019Trial
- Efficacy and safety of antifungal prophylaxis in surgical intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials.Biomedical reports · 2026Article
- Age-Comorbidity Interactions and Clinical Outcomes in Septic Shock: An Emergency Department-Based Multicenter Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Predictors of Extended Length of Stay Following Open Reduction and Internal Fixation for Distal Radius Fractures.Journal of wrist surgery · 2025Article
- Management Protocols for Sepsis and Septic Shock after Craniotomy: Clinical Outcomes and Survival Analysis.Asian journal of neurosurgery · 2025Article
- Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients.Critical care (London, England) · 2025Article
- Association between sepsis and all-cause and cause-specific premature mortality: a prospective cohort study.Frontiers in public health · 2025Article
- Adverse postoperative outcomes in elderly patients with sarcopenia.BMC geriatrics · 2024Article
- Postoperative bioactive adrenomedullin is associated with the onset of ARDS and adverse outcomes in patients undergoing open thoracoabdominal aortic surgery.Scientific reports · 2024Article
- Preventable deaths involving sepsis in England and Wales, 2013-2022: a systematic case series of coroners' reports.Infection · 2024Article
- The iNKT cell ligand α-GalCer prevents murine septic shock by inducing IL10-producing iNKT and B cells.Frontiers in immunology · 2024Article
- Article
- Artificial Intelligence for Risk Prediction of Rehospitalization with Acute Kidney Injury in Sepsis Survivors.Journal of personalized medicine · 2022Article
- Factors associated with mortality of pediatric sepsis patients at the pediatric intensive care unit in a low-resource setting.BMC pediatrics · 2021Article
- Using machine learning methods to predict in-hospital mortality of sepsis patients in the ICU.BMC medical informatics and decision making · 2020Article
- Surgical site infections in a tertiary hospital over 10 years. The effect of hospital accreditation strategy implementation.Saudi medical journal · 2020Article
- A Machine Learning-Based Prediction of Hospital Mortality in Patients With Postoperative Sepsis.Frontiers in medicine · 2020Article
- The Impacts of Deep Surgical Site Infections on Readmissions, Length of Stay, and Costs: A Matched Case-Control Study Conducted in an Academic Hospital in the Netherlands.Infection and drug resistance · 2020Article
- Hidden hospital mortality in patients with sepsis discharged from the intensive care unit.Revista Brasileira de terapia intensiva · 2019Observational
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Authors and funding
7 authors.
Funding
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Abstract
backgroundOur aim in the present study was to assess the mortality impact of hospital-acquired post-operative sepsis up to 1 year after hospital discharge among adult non-short-stay elective surgical patients.
methodsWe conducted a population-based, retrospective cohort study of all elective surgical patients admitted to 82 public acute hospitals between 1 January 2007 and 31 December 2012 in New South Wales, Australia. All adult elective surgical admission patients who stayed in hospital for ≥4 days and survived to discharge after post-operative sepsis were identified using the Admitted Patient Data Collection records linked with the Registry of Births, Deaths, and Marriages. We assessed post-discharge mortality rates at 30 days, 60 days, 90 days and 1 year and compared them with those of patients without post-operative sepsis.
resultsWe studied 144,503 survivors to discharge. Of these, 1857 (1.3%) had experienced post-operative sepsis. Their post-discharge mortality rates at 30 days, 60 days, 90 days and 1 year were 4.6%, 6.7%, 8.1% and 13.5% (vs 0.7%, 1.2%, 1.5% and 3.8% in the non-sepsis cohort), respectively (P < 0.0001 for all). After adjustment for patient and hospital characteristics, post-operative sepsis remained independently associated with a higher mortality risk (30-day mortality HR 2.75, 95% CI 2.14-3.53; 60-day mortality HR 2.45, 95% CI 1.94-3.10; 90-day mortality HR 2.31, 95% CI 1.85-2.87; 1-year mortality HR 1.71, 95% CI 1.46-2.00). Being older than 75 years of age (HR 3.50, 95% CI 1.56-7.87) and presence of severe/very severe co-morbidities as defined by Charlson co-morbidity index (severe vs normal HR 2.05, 95% CI 1.45-2.89; very severe vs normal HR 2.17, 95% CI 1.49-3.17) were the only other significant independent predictors of increased 1-year mortality.
conclusionsAmong elective surgical patients, post-operative sepsis is independently associated with increased post-discharge mortality up to 1 year after hospital discharge. This risk is particularly high in the first month, in older age patients and in the presence of severe/very severe co-morbidities. This high-risk population can be targeted for interventions.
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