ArticleBMC nephrology2017
β-trace protein is highly removed during haemodialysis with high-flux and super high-flux membranes.
Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Flummoxed by flux: the indeterminate principles of haemodialysis.Clinical kidney journal · 2021Review
- Beta-trace protein as a potential biomarker of residual renal function in patients undergoing peritoneal dialysis.BMC nephrology · 2021Article
- Measuring serum beta2-microglobulin to predict long-term mortality in hemodialysis patients using low-flux dialyzer reuse.Therapeutics and clinical risk management · 2019Article
- What a Clinician Should Know About a Renal Replacement Membrane?Journal of translational internal medicine · 2018Article
- Measurement and Estimation of Residual Kidney Function in Patients on Dialysis.Advances in chronic kidney disease · 2018Review
- Development and Validation of Residual Kidney Function Estimating Equations in Dialysis Patients.Kidney medicineArticle
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Authors and funding
4 authors.
Funding
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Abstract
backgroundSerum β-trace protein (βTP, MW 23-29 kDa) is a marker of GFR impairment in renal patients. Recent papers propose to predict residual renal function (RRF) in maintenance haemodialysis (MHD) patients from serum concentrations of βTP and other small proteins, avoiding the collection of urine. Few data are available on the removal of βTP in patients treated with dialysis membranes with different flux characteristics. The aim of this study was to evaluate the effects of haemodialysis with low-flux, high-flux and super high-flux membranes on serum concentrations of ßTP in MHD patients with null RRF.
methodsSerum ßTP concentrations were measured before and after the first dialysis of the week in 51 MDH patients treated by low-flux (n = 24), high-flux (n = 17), or super high-flux (n = 10) membranes. The removal of β2-microglobulin (β2M, MW 11.8), cystatin C (Cys, MW 13.3), urea and creatinine was also analyzed.
resultsLow-flux membranes did not remove βTP, β2M and Cys whose concentration increased at the end of dialysis. High-flux membrane removed more efficiently β2M and Cys than ßTP. Super high-flux membrane had the highest efficiency to remove ßTP: mean reduction ratio (RR) 53.4%, similar to β2M (59.5%), and Cys (62.0%).
conclusionsIn conclusion, the plasma clearance of small proteins and particularly of βTP is dependent from the permeability of the dialysis membranes Therefore, the reliability of the formulas proposed to predict RRF from serum βTP and other LMWP may be affected by the different permeability of the dialysis membranes.
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