ArticleBMC infectious diseases2017
Genetic Characterization of Vibrio cholerae O1 isolates from outbreaks between 2011 and 2015 in Tanzania.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Genomic epidemiology reveals geographically structured co-circulation of AFR10 and AFR13Microbial genomics · 2026Article
- Genome-wide investigation of outbreak-associatedFrontiers in microbiology · 2026Article
- Genomic analysis and antimicrobial resistance ofMicrobial genomics · 2025Article
- Whole genome sequencing and transmission analysis ofmedRxiv : the preprint server for health sciences · 2025Article
- Genomic epidemiology reveals multidrug resistant plasmid spread between Vibrio cholerae lineages in Yemen.Nature microbiology · 2023Article
- Article
- Three transmission events of Vibrio cholerae O1 into Lusaka, Zambia.BMC infectious diseases · 2021Article
- Genomic analysis of pathogenic isolates of Vibrio cholerae from eastern Democratic Republic of the Congo (2014-2017).PLoS neglected tropical diseases · 2020Article
- Characterisation ofThe Pan African medical journal · 2020Article
- Genomic insights into Vibrio cholerae O1 responsible for cholera epidemics in Tanzania between 1993 and 2017.PLoS neglected tropical diseases · 2019Article
- Review
- Cholera: an overview with reference to the Yemen epidemic.Frontiers of medicine · 2019Review
- Review of molecular subtyping methodologies used to investigate outbreaks due to multidrug-resistant enteric bacterial pathogens in sub-Saharan Africa.African journal of laboratory medicine · 2019Review
- Article
- Surveillance and Genomics of ToxigenicFrontiers in microbiology · 2019Article
- Comparative Genomics and Phylogenomic Analysis of the GenusFrontiers in microbiology · 2019Article
- Molecular characterization of Vibrio cholerae responsible for cholera epidemics in Uganda by PCR, MLVA and WGS.PLoS neglected tropical diseases · 2018Article
- Cholera Epidemic in South Sudan and Uganda and Need for International Collaboration in Cholera Control.Emerging infectious diseases · 2018Article
- Genetic relatedness of Vibrio cholerae isolates within and between households during outbreaks in Dhaka, Bangladesh.BMC genomics · 2017Article
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16 authors.
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Abstract
backgroundCholera outbreaks have occurred in Tanzania since 1974. To date, the genetic epidemiology of these outbreaks has not been assessed.
methods96 Vibrio cholerae O1 isolates from five regions were characterized, and their genetic relatedness assessed using multi-locus variable-number tandem-repeat analysis (MLVA) and whole genome sequencing (WGS).
resultsOf the 48 MLVA genotypes observed, 3 were genetically unrelated to any others, while the remaining 45 genotypes separated into three MLVA clonal complexes (CCs) - each comprised of genotypes differing by a single allelic change. In Kigoma, two separate outbreaks, 4 months apart (January and May, 2015), were each caused by genetically distinct strains by MLVA and WGS. Remarkably, one MLVA CC contained isolates from both the May outbreak and ones from the 2011/2012 outbreak in Dar-es-Salaam. However, WGS revealed the isolates from the two outbreaks to be distinct clades. The outbreak that started in August 2015 in Dar-es-Salaam and spread to Morogoro, Singida and Mara was comprised of a single MLVA CC and WGS clade. Isolates from within an outbreak were closely related differing at fewer than 5 nucleotides. All isolates were part of the 3
conclusionsWe conclude that genetically related V. cholerae cluster in outbreaks, and distinct strains circulate simultaneously.
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