ArticleNature chemical biology2017
Engineering fatty acid synthases for directed polyketide production.
Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Engineering metazoan fatty acid synthase to control chain length applied in yeast.Nature chemical biology · 2026Article
- Braess' Paradox in Enzyme Kinetics: Asymmetry from Population Balance without Direct Cooperativity.Journal of chemical theory and computation · 2026Article
- Structural basis of product recognition by Mycobacterium tuberculosis fatty acid synthase.Protein science : a publication of the Protein Society · 2026Article
- The enzyme kinetics of branched-chain fatty acid synthesis of metazoan fatty acid synthase.Protein science : a publication of the Protein Society · 2025Article
- Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides.International journal of molecular sciences · 2023Review
- Ketosynthase mutants enable short-chain fatty acid biosynthesis in E. coli.Metabolic engineering · 2023Article
- Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases.ACS catalysis · 2021Article
- The sporothriolides. A new biosynthetic family of fungal secondary metabolites.Chemical science · 2020Article
- Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis.Biochemistry · 2020Article
- Interfacial plasticity facilitates high reaction rate ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fusing α and β subunits of the fungal fatty acid synthase leads to improved production of fatty acids.Scientific reports · 2020Article
- Toward fine-tuned metabolic networks in industrial microorganisms.Synthetic and systems biotechnology · 2020Article
- Article
- Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).Scientific reports · 2020Article
- Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase.Scientific reports · 2019Article
- Molecular basis for interactions between an acyl carrier protein and a ketosynthase.Nature chemical biology · 2019Article
- Article
- Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I.Protein science : a publication of the Protein Society · 2019Article
- Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases.Methods in enzymology · 2019Article
- Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase.The FEBS journal · 2018Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.
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