Evidence map›Paper›PMID 28218614›Full record

ArticlePhysics in medicine and biology2017

First in vivo magnetic particle imaging of lung perfusion in rats.

Xinyi Y Zhou, Kenneth E Jeffris, Elaine Y Yu, Bo Zheng, Patrick W Goodwill, Payam Nahid, Steven M Conolly

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 124 citations in OpenAlex.

  1. Review
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  6. On the partial volume effect in magnetic particle imaging.Physics in medicine and biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Novel Auger-Electron-EmittingPharmaceuticals (Basel, Switzerland) · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Application of magnetic particle imaging to evaluate nanoparticle fate in rodent joints.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xinyi Y ZhouUC Berkeley-UCSF Graduate Program in Bioengineering, Berkeley, CA 94720, United States of America.
Kenneth E JeffrisDepartment of Bioengineering, University of California Berkeley, Berkeley, CA 94720, United States of America.
Elaine Y YuUC Berkeley-UCSF Graduate Program in Bioengineering, Berkeley, CA 94720, United States of America.
Bo ZhengDepartment of Bioengineering, University of California Berkeley, Berkeley, CA 94720, United States of America.
Patrick W GoodwillMagnetic Insight Inc., Newark CA 94560, United States of America.
Payam NahidDivision of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, CA 94143, United States of America.
Steven M ConollyDepartment of Bioengineering, University of California Berkeley, Berkeley, CA 94720, United States of America.
University of California, Berkeley · US

Funding

Pre-clinical quantitation of ovarian cancer tumor burden using Magnetic Particle Imaging and non-dilutive cell labelingR01EB019458 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI BELL, CALEB B., CONOLLY, STEVEN M · 2015 to 2018
$1.9M
Magnetic Particle Imaging (MPI) for Functional Brain Imaging in HumansR24MH106053 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI CONOLLY, STEVEN M, GRISWOLD, MARK · 2014 to 2016
$1.5M
NIBIB NIH HHS R01 EB019458NIMH NIH HHS R24 MH106053
6 · The paper itself

Abstract

Pulmonary embolism (PE), along with the closely related condition of deep vein thrombosis, affect an estimated 600 000 patients in the US per year. Untreated, PE carries a mortality rate of 30%. Because many patients experience mild or non-specific symptoms, imaging studies are necessary for definitive diagnosis of PE. Iodinated CT pulmonary angiography is recommended for most patients, while nuclear medicine-based ventilation/perfusion (V/Q) scans are reserved for patients in whom the use of iodine is contraindicated. Magnetic particle imaging (MPI) is an emerging tracer imaging modality with high image contrast (no tissue background signal) and sensitivity to superparamagnetic iron oxide (SPIO) tracer. Importantly, unlike CT or nuclear medicine, MPI uses no ionizing radiation. Further, MPI is not derived from magnetic resonance imaging (MRI); MPI directly images SPIO tracers via their strong electronic magnetization, enabling deep imaging of anatomy including within the lungs, which is very challenging with MRI. Here, the first high-contrast in vivo MPI lung perfusion images of rats are shown using a novel lung perfusion agent, MAA-SPIOs.

Indexed as

Magnetite NanoparticlesAnimalsDiagnostic ImagingFemaleLungPerfusion ImagingPulmonary EmbolismRatsRats, Inbred F344Magnetite Nanoparticles

Identifiers

PMID28218614
PMCPMC5734624
OpenAlexW2591389465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.