Evidence map›Paper›PMID 28218420›Full record

Trial reportMolecular carcinogenesis2017

Plasma lipoxin A

Veronika Fedirko, Gail McKeown-Eyssen, Charles N Serhan, Elizabeth L Barry, Robert S Sandler, Jane C Figueiredo, Dennis J Ahnen, Robert S Bresalier, Douglas J Robertson, Carlton W Anderson and 1 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Molecular carcinogenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 2 countries.

Veronika FedirkoDepartment of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, Georgia.ORCID 0000-0002-7805-9913
Gail McKeown-EyssenDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Charles N SerhanDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital & Harvard Medical School, Center for Experimental Therapeutics and Reperfusion Injury, Boston, Massachusetts.
Elizabeth L BarryDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Robert S SandlerDepartment of Medicine, University of North Carolina, Chapel Hill, North Carolina.
Jane C FigueiredoDepartment of Preventive Medicine, Keck School Of Medicine, University of Southern California, Los Angeles, California.
Dennis J AhnenDepartment of Veterans Affairs Medical Center, Denver, Colorado.
Robert S BresalierDepartment of Gastrointestinal Medicine and Nutrition, University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Douglas J RobertsonDepartment of Veterans Affairs Medical Center, White River Junction VT and The Dartmouth Institute for Health Policy and Clinical Practice, Dartmouth Medical School, Lebanon, New Hampshire.
Carlton W AndersonCenter for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
John A BaronDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
University of North Carolina at Chapel Hill · USBrigham and Women's Hospital · USDartmouth College · USDartmouth Institute for Health Policy and Clinical Practice · USEmory University · USThe University of Texas MD Anderson Cancer Center · USUnited States Department of Veterans Affairs · USUniversity of Southern California · USUniversity of Toronto · CA

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Relation Between In-utero Vitamin D and Immune Function in Early Childhood P20GM104416 · NIGMS · DARTMOUTH COLLEGE · PI KARAGAS, MARGARET RITA · 2013 to 2022
$23.7M
FOLATE, DNA METHYLATION AND CARCINOGENESIS IN THE BOWELR01CA059005 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARON, JOHN ANTHONY · 1993 to 2013
$17.3M
BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTIONR37GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2000 to 2009
$4.0M
Vitamin D3, Calcium and Biomarkers of Gut Barrier FunctionR21CA182752 · NCI · EMORY UNIVERSITY · PI FEDIRKO, VERONIKA · 2014 to 2015
$389k
Vitamin D3, Calcium and Inflammation, Immunomodulation and Colonic PermeabilityR03CA184578 · NCI · EMORY UNIVERSITY · PI FEDIRKO, VERONIKA · 2014 to 2015
$171k
NCI NIH HHS R01 CA059005NCI NIH HHS R03 CA184578NCI NIH HHS R21 CA182752NIDDK NIH HHS P30 DK034987NIGMS NIH HHS P20 GM104416NIGMS NIH HHS R37 GM038765
6 · The paper itself

Abstract

Inflammation plays a major role in colon carcinogenesis. Endogenously produced specialized proresolving lipid mediators (SPMs) play a central role in inflammation and tissue homeostasis, and have been implicated in carcinogenesis. We studied the associations of plasma levels of two SPMs [lipoxin A

Indexed as

AdenomaAgedAnti-Inflammatory Agents, Non-SteroidalAspirinColonColorectal NeoplasmsDocosahexaenoic AcidsFemaleFolic AcidHumansLipoxinsMaleMiddle AgedPilot ProjectsRectumRiskAnti-Inflammatory Agents, Non-SteroidalAspirinDocosahexaenoic AcidsFolic Acidlipoxin A4Lipoxinsresolvin D1Vitamin B Complexaspirincolorectal neoplasmslipoxin A4randomized controlled trialresolvin D1

Identifiers

PMID28218420
PMCPMC5496792
OpenAlexW2589204380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.