Evidence map›Paper›PMID 28218275›Full record

ArticleNature communications2017

Gate-controlled conductance switching in DNA.

Limin Xiang, Julio L Palma, Yueqi Li, Vladimiro Mujica, Mark A Ratner, Nongjian Tao

Abstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Toward Practical Single-Molecule/Atom Switches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. A Chemically Soldered Polyoxometalate Single-Molecule Transistor.Angewandte Chemie (International ed. in English) · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. An active DNA-based nanoprobe for photoacoustic pH imaging.Chemical communications (Cambridge, England) · 2018
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Limin XiangBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.
Julio L PalmaBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.
Yueqi LiBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.
Vladimiro MujicaSchool of Molecular Sciences, Arizona State University, Tempe, Arizona 85287, USA.
Mark A RatnerDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, USA.
Nongjian TaoBiodesign Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive evidence has shown that long-range charge transport can occur along double helical DNA, but active control (switching) of single-DNA conductance with an external field has not yet been demonstrated. Here we demonstrate conductance switching in DNA by replacing a DNA base with a redox group. By applying an electrochemical (EC) gate voltage to the molecule, we switch the redox group between the oxidized and reduced states, leading to reversible switching of the DNA conductance between two discrete levels. We further show that monitoring the individual conductance switching allows the study of redox reaction kinetics and thermodynamics at single molecular level using DNA as a probe. Our theoretical calculations suggest that the switch is due to the change in the energy level alignment of the redox states relative to the Fermi level of the electrodes.

Indexed as

Electric ConductivityThermodynamicsAnthraquinonesCircular DichroismDNAElectrochemical TechniquesModels, MolecularMolecular StructureNucleic Acid ConformationOxidation-ReductionAnthraquinonesDNA

Identifiers

PMID28218275
PMCPMC5321735

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.