ArticleScientific reports2017
Complexity Variability Assessment of Nonlinear Time-Varying Cardiovascular Control.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Integration of Multi-Modal Biosensing Approaches for Depression: Current Status, Challenges, and Future Perspectives.Sensors (Basel, Switzerland) · 2025Review
- Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group.Scientific reports · 2024Article
- Sympathetic and parasympathetic central autonomic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures.JMIR mental health · 2023Review
- Head hemodynamics and systemic responses during auditory stimulation.Physiological reports · 2022Article
- Exploring the Dynamics of Week-to-Week Blood Pressure in Nursing Home Residents Before Death.American journal of hypertension · 2022Article
- Cardiac Autonomic Modulation in Subjects with Amyotrophic Lateral Sclerosis (ALS) during an Upper Limb Virtual Reality Task: A Prospective Control Trial.BioMed research international · 2022Article
- Plethysmography System to Monitor the Jugular Venous Pulse: A Feasibility Study.Diagnostics (Basel, Switzerland) · 2021Article
- Influence of Obesity on Heart Rate Variability in Nurses with Age and Shift Type as Moderators.BioMed research international · 2021Article
- Assessing Autonomic Function from Electrodermal Activity and Heart Rate Variability During Cold-Pressor Test and Emotional Challenge.Scientific reports · 2020Article
- Uncovering complex central autonomic networks at rest: a functional magnetic resonance imaging study on complex cardiovascular oscillations.Journal of the Royal Society, Interface · 2020Article
- Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling.Frontiers in physiology · 2020Article
- Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to high altitude.Scientific reports · 2019Article
- The application of Lempel-Ziv and Titchener complexity analysis for equine telemetric electrocardiographic recordings.Scientific reports · 2019Article
- Dynamic coupling between the central and autonomic nervous systems during sleep: A review.Neuroscience and biobehavioral reviews · 2018Review
- Effects of Coexistence Hypertension and Type II Diabetes on Heart Rate Variability and Cardiorespiratory Fitness.Arquivos brasileiros de cardiologia · 2018Article
- Meditation-Induced Coherence and Crucial Events.Frontiers in physiology · 2018Article
- Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology.Journal of Alzheimer's disease : JAD · 2018Review
- Detecting abnormality in heart dynamics from multifractal analysis of ECG signals.Scientific reports · 2017Article
- MEIS1 variant as a determinant of autonomic imbalance in Restless Legs Syndrome.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
Abstract
The application of complex systems theory to physiology and medicine has provided meaningful information about the nonlinear aspects underlying the dynamics of a wide range of biological processes and their disease-related aberrations. However, no studies have investigated whether meaningful information can be extracted by quantifying second-order moments of time-varying cardiovascular complexity. To this extent, we introduce a novel mathematical framework termed complexity variability, in which the variance of instantaneous Lyapunov spectra estimated over time serves as a reference quantifier. We apply the proposed methodology to four exemplary studies involving disorders which stem from cardiology, neurology and psychiatry: Congestive Heart Failure (CHF), Major Depression Disorder (MDD), Parkinson's Disease (PD), and Post-Traumatic Stress Disorder (PTSD) patients with insomnia under a yoga training regime. We show that complexity assessments derived from simple time-averaging are not able to discern pathology-related changes in autonomic control, and we demonstrate that between-group differences in measures of complexity variability are consistent across pathologies. Pathological states such as CHF, MDD, and PD are associated with an increased complexity variability when compared to healthy controls, whereas wellbeing derived from yoga in PTSD is associated with lower time-variance of complexity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.