ArticleEndoscopic ultrasound
B-mode and contrast-enhancement characteristics of small nonincidental neuroendocrine pancreatic tumors.
Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Contrast-enhanced endoscopic ultrasonography differentiated pancreatic schwannoma from concurrent neuroendocrine tumor.Clinical journal of gastroenterology · 2026Article
- Glucagonoma and Glucagonoma Syndrome: An Updated Review.Clinical endocrinology · 2025Review
- Review
- Usefulness of detective flow imaging endoscopic ultrasound for pancreatic neuroendocrine tumors difficult to detect with other imaging modalities.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Article
- Portuguese Pancreatic Club Perspectives on Pancreatic Neuroendocrine Neoplasms: Diagnosis and Staging, Associated Genetic Syndromes and Particularities of Their Clinical Approach.GE Portuguese journal of gastroenterology · 2024Review
- Contrast-enhanced guided endoscopic ultrasound procedures.World journal of gastroenterology · 2024Review
- Review
- Contrast Enhanced EUS for Predicting Solid Pancreatic Neuroendocrine Tumor Grade and Aggressiveness.Diagnostics (Basel, Switzerland) · 2023Review
- Prediction of Pancreatic Neuroendocrine Tumor Grading Risk Based on Quantitative Radiomic Analysis of MR.Frontiers in oncology · 2021Article
- Multivisceral robotic resection: a glimpse into the future of minimally invasive abdominal surgery.BMJ case reports · 2020Article
- Modern ultrasound imaging of pancreatic tumors.Ultrasonography (Seoul, Korea) · 2020Article
- WFUMB position paper on the management incidental findings: adrenal incidentaloma.Ultrasonography (Seoul, Korea) · 2020Article
- Diagnostic imaging of gastrointestinal neuroendocrine neoplasms with a focus on ultrasound.Journal of ultrasonography · 2019Review
- Clinical use of contrast-enhanced ultrasound beyond the liver: a focus on renal, splenic, and pancreatic applications.Ultrasonography (Seoul, Korea) · 2019Article
- Late metachronous isolated pancreatic metastasis from renal cell carcinoma mimicking a pancreatic neuroendocrine tumor.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Present status and perspectives of endosonography 2017 in gastroenterology.The Korean journal of internal medicine · 2018Review
- The resectable pancreatic ductal adenocarcinoma: To FNA or not to FNA? A diagnostic dilemma, introduction.Endoscopic ultrasound · 2017Article
- Contrast-enhanced ultrasound of small focal solid pancreatic lesions: A must!Endoscopic ultrasound · 2017Article
- Diagnosis of Pancreatic Neuroendocrine Tumors.Clinical endoscopy · 2017Review
- Catching the Zebra: Clinical Pearls and Pitfalls for the Successful Diagnosis of Zollinger-Ellison Syndrome.Digestive diseases and sciences · 2017Review
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Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesImaging of the pancreas for detection of neuroendocrine tumors is indicated as surveillance in multiple endocrine neoplasia type 1 (MEN1) or if typical clinical symptoms combined with hormone production raise the suspicion of a neuroendocrine tumor. Endoscopic ultrasound (EUS) is considered the best imaging modality to detect small pancreatic tumors. However, little is known about how small pancreatic neuroendocrine tumors (pNETs) present on EUS. PATIENTS AND
methodsIn this multicenter study, we retrospectively analyzed the endosonographic characteristics of small pNETs which had been detected due to typical biochemistry and clinical symptoms or during surveillance of MEN 1. Only small pancreatic tumors ≤15 mm with histological confirmation as pNET were included. B-mode and contrast-enhanced ultrasound- and EUS patterns were analyzed.
resultsAmong 32 patients with histologically proven small pNETs, 7 patients had known MEN1. Among the pNETs, 20 were insulinoma, 2 gastrinoma, 3 glucagonoma, 6 nonfunctional in MEN1, and one PPoma. 94% of the pNET appeared hypoechogenic, only 1 isoechogenic and 1 hyperechogenic. After contrast injection, 90% of the pNETS showed hyperenhancement compared to the surrounding pancreatic parenchyma.
conclusionThe high spatial resolution of EUS allows detection and even cytological confirmation of pNET <7 mm diameter. Hypoechogenicity in B-mode and hyperenhancement after injection of contrast agents are endosonographic characteristics of small pNET and present in >90% of pNETs.
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