Evidence map›Paper›PMID 28217978›Full record

ArticleEuropean journal of heart failure2017

The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction.

Matthew Nayor, Martin G Larson, Na Wang, Rajalakshmi Santhanakrishnan, Douglas S Lee, Connie W Tsao, Susan Cheng, Emelia J Benjamin, Ramachandran S Vasan, Daniel Levy and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of heart failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  2. Highlights in heart failure.ESC heart failure · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Matthew NayorNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Martin G LarsonNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Na WangData Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
Rajalakshmi SanthanakrishnanSection of Cardiovascular Medicine, Department of Medicine, Boston University, Boston, MA, USA.
Douglas S LeeInstitute for Clinical Evaluative Sciences, University of Toronto, Toronto, Canada.
Connie W TsaoNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Susan ChengNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Emelia J BenjaminNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Ramachandran S VasanNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Daniel LevyNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Caroline S FoxNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Jennifer E HoNational Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.
Boston University · USFramingham Heart Study · USNational Heart Lung and Blood Institute · USBrigham and Women's Hospital · USUniversity Health Network · CA

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
TRAINING PROGRAM IN CARDIOVASCULAR RESEARCHT32HL007604 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MARK W FEINBERG · 1985 to 2026
$19.0M
Harvard Regional Clinical Center of the NHLBI Heart Failure NetworkU10HL110337 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GIVERTZ, MICHAEL M, LEWIS, GREGORY DYER · 2012 to 2018
$3.5M
The Role of Galectin-3 in Cardiac Remodeling and Heart FailureK23HL116780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HO, JENNIFER E · 2013 to 2017
$832k
Myocardial and Arterial Aging: Spectrum, Correlates, and PrognosisR00HL107642 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHENG, SUSAN · 2014 to 2016
$747k
Determinants and Prognostic Significance of Proximal Aortic StiffnessK23HL118529 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSAO, CONNIE · 2014 to 2018
$742k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
CIHRNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL116780NHLBI NIH HHS K23 HL118529NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R00 HL107642NHLBI NIH HHS T32 HL007604NHLBI NIH HHS U10 HL110337
6 · The paper itself

Abstract

aimsChronic kidney disease (CKD) and microalbuminuria are associated with incident heart failure (HF), but their relative contributions to HF with preserved vs. reduced EF (HFpEF and HFrEF) are unknown. We sought to evaluate the associations of CKD and microalbuminuria with incident HF subtypes in the community-based Framingham Heart Study (FHS). METHODS AND

resultsWe defined CKD as glomerular filtration rate <60 mL/min/1.73 m

conclusionsMicroalbuminuria was associated with incident HFrEF prospectively, and with LV systolic dysfunction cross-sectionally in a community-based sample. In contrast, CKD was modestly associated with overall HF but not differentially associated with HFpEF vs. HFrEF. The mechanisms responsible for the relationship of microalbuminuria to future development of HFrEF warrant further investigation.

Indexed as

ForecastingAgedAlbuminuriaBiomarkersCross-Sectional StudiesFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedPrevalencePrognosisRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsBiomarkersCardiorenal syndromeEpidemiologyHeart failureKidney diseaseMicroalbuminuriaPrevention

Identifiers

PMID28217978
PMCPMC5423843
OpenAlexW2589800099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.