ReviewThe Journal of physiology2017
Hypertension-induced remodelling: on the interactions of cardiac risk factors.
Review in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 80 citations in OpenAlex.
- Understanding the Mortality Trends in Patients With Ventricular Arrhythmias and Cardiomyopathy: A 25-Year Retrospective Analysis From 1999-2024.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Observational
- Novel method for risk stratification of radiation-induced breast fibrosis: subgroup hypothesis verified by machine learning.NPJ breast cancer · 2026Article
- Cardiomyopathy in women with acromegaly: clinical characteristics and associated factors in a Colombian multicenter registry.Frontiers in endocrinology · 2026Article
- Effects of Chicken Protein Hydrolysate Supplementation Alone or Combined With Concurrent Training on Arterial Stiffness in Adults With Hypertension: A Randomized Controlled Trial.International journal of hypertension · 2026Article
- Left Ventricular Remodeling After Myocardial Infarction-Pathophysiology, Diagnostic Approach and Management During Cardiac Rehabilitation.International journal of molecular sciences · 2025Review
- Exploring the Impact of E-cigarettes on Cardiovascular Health: Insights from Preclinical and Clinical Studies.Cardiovascular toxicology · 2025Review
- Functional Roles of the Complement Immune System in Cardiac Inflammation and Hypertrophy.International journal of molecular sciences · 2025Review
- Hypertensive BPH/2J mice exhibit sex-specific heart failure progression and late-life microvascular rarefaction.American journal of physiology. Heart and circulatory physiology · 2025Article
- Three-Year Echocardiographic Follow-Up in Outpatients with Systemic Arterial Hypertension: An Observational Cohort Study.Journal of clinical medicine · 2025Article
- Cardiac macrophage: Insights from murine models to translational potential for human studies.Journal of molecular and cellular cardiology · 2025Review
- Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction.Nature cardiovascular research · 2025Article
- Explainable AI associates ECG aging effects with increased cardiovascular risk in a longitudinal population study.NPJ digital medicine · 2025Article
- Machine learning-based nomogram predicts heart failure risk in elderly relapsed/refractory multiple myeloma patients receiving carfilzomib-based therapy.Frontiers in oncology · 2025Article
- Protecting the Heart in Motion: The Role of Physical Activity and Cardiorespiratory Fitness in Preventing Sudden Cardiac Death.Clinical Medicine Insights. Cardiology · 2025Review
- Fractal analysis of left ventricular trabeculae in hypertensive patients with heart failure: a 3.0 T cardiac magnetic resonance study.Frontiers in cardiovascular medicine · 2025Article
- Expert Opinion on the Role of Sacubitril/Valsartan in the Management of Hypertension in India.Cardiology and therapy · 2024Review
- Impact of surgical and non-surgical weight loss on echocardiographic and strain parameters in Asian patients.Scientific reports · 2024Article
- Effects of voluntarily consumed sweetened alcohol and naringin on cardiac function in male and female Sprague-Dawley rats.Physiological reports · 2024Article
- Predictive characteristics and model development for acute heart failure preceding hip fracture surgery in elderly hypertensive patients: a retrospective machine learning approach.BMC geriatrics · 2024Article
- Renin-angiotensin system inhibition after surgical aortic valve replacement for aortic stenosis.Heart (British Cardiac Society) · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypertension induces considerable cardiac remodelling, such as hypertrophy, interstitial fibrosis, and abnormal activity of the cardiac sympathetic nervous system, which are established risk factors in several highly dangerous heart diseases, such as ventricular fibrillation and congestive heart failure. All these risk factors and heart diseases are studied extensively in isolation, but to our knowledge, there is no comprehensive review of their interactions. At the same time, there is growing evidence suggesting that such interactions are numerous and that a successful therapy against a particular condition may have unexpectedly weak effects on mortality, as treated patients may die of a different cause exacerbated by the therapy. In this article, we present a multiscale review of the literature focusing on the relationships between the above-mentioned risk factors and heart diseases, and introduce a framework that gives insight into their possible interactions. We use this framework to demonstrate that conditions such as fibrosis and elevated activity of the sympathetic nervous system may be compensatory, rather than purely pathological, mechanisms in certain contexts. Finally, we show why the described mechanisms are relevant not only in hypertension, but also in the case of healed myocardial infarction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.