ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Frontal Gamma-Aminobutyric Acid Concentrations Are Associated With Cognitive Performance in Older Adults.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06284720 (Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults), which is not on this map. Cited by 121 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults
Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it, 201 citations in OpenAlex.
- Pooled it
- Co-ultramicronized palmitoylethanolamide/luteolin normalizes GABAClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Trial
- Dynamic Recovery: GABA Agonism Restores Neural Variability in Older, Poorer Performing Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Trial
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Prolonged morning wake transitions associated with amyloid beta burden: A cross-sectional pilot study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum.Autism research : official journal of the International Society for Autism Research · 2026Article
- Eukaryotic initiation factor 4E: a key factor of traumatic stress-induced depression-related cognitive decline at different age.Translational psychiatry · 2026Article
- The Tip-of-the-Tongue Phenomenon: Cognitive, Neural, and Neurochemical Perspectives.Biomedicines · 2026Review
- AI-enabled multimodal neuroimaging for neurotransmitter mapping in normal aging and age-related disease.Frontiers in aging neuroscience · 2026Review
- Age-dependent alterations in anterior cingulate excitation-inhibition balance in major depressive disorder revealed by 7-Tesla magnetic resonance spectroscopy.NeuroImage. Clinical · 2026Article
- Neurochemical changes in GABA+, Glx, and the excitatory/inhibitory ratio in the calcarine cortex with healthy aging.NeuroImage · 2025Article
- Prefrontal inhibitory mechanisms associated with Putamen activity during valence learning revealed by multimodal fMRI-fMRS.Communications biology · 2025Article
- Relationships between GABA + and Glx concentrations with age and inhibition in healthy older adults.Brain structure & function · 2025Article
- Neurophysiological correlates of modifiable dementia risk factors in cognitively unimpaired older adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Article
- Hippocampal and prefrontal GABA and glutamate concentration contribute to component processes of working memory in aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Synthesis of versatile neuromodulatory molecules by a gut microbial glutamate decarboxylase.iScience · 2025Article
- Modulation of brain signal variability in visual cortex reflects aging, GABA, and behavior.eLife · 2025Article
- The role of inhibitory and excitatory neurometabolites in age-related differences in action selection.npj aging · 2025Article
- "Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.Translational psychiatry · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 2 countries.
Eric C PorgesCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Adam J WoodsCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Richard A E EddenCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Nicolaas A J PutsCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Ashley D HarrisCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Huaihou ChenCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Amanda M GarciaCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Talia R SeiderCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Damon G LambCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
John B WilliamsonCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Ronald A CohenCenter for Cognitive Aging and Memory (ECP, AJW, HC, AMG, TRS, DGL, JBW, RAC), Institute on Aging, McKnight Brain Institute, Department of Aging and Geriatric Research; Department of Neuroscience (AJW), University of Florida, Gainesville, Florida; FM Kirby Center for Functional Brain Imaging (RAEE, NAJP, ADH), Kennedy Krieger Institute; Russell H. Morgan Department of Radiology and Radiological Science (RAEE, NAJP, ADH), The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Radiology (ADH), CAIR Program (ADH), Alberta Children's Hospital Research Institute, University of Calgary; Hotchkiss Brain Institute (ADH), University of Calgary, Calgary, Alberta, Canada; Department of Biostatistics (HC); Department of Clinical and Health Psychology (AMG, TRS), University of Florida; Brain Rehabilitation and Research Center (DGL, JBW), Malcom Randall Veterans Affairs Medical Center; and Center for Neuropsychological Studies (JBW), Department of Neurology, University of Florida College of Medicine, Gainesville, Florida.
Allen Institute for Brain Science · USKennedy Krieger Institute · US
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MUniversity of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8MVirology CoreP01AA019072 · NIAAA · BROWN UNIVERSITY · PI LIU, TAO · 2010 to 2024
$19.7MTR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1MUF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2MTogether: Transforming and Translating Discovery to Improve HealthKL2TR001429 · NCATS · UNIVERSITY OF FLORIDA · PI GUIRGIS, FAHEEM W, LEEUWENBURGH, CHRISTIAAN · 2015 to 2023
$5.5MUniversal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4MUF Clinical and Translational Science AwardKL2TR000065 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$1.6MA Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderK99MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2016 to 2017
$165kAlcohol interventions for Mandated Students (Project AIMS)F31AA018238 · NIAAA · UNIVERSITY OF WASHINGTON · PI LOGAN, DIANE E · 2009 to 2011
$86kNCATS NIH HHS KL2 TR000065NCATS NIH HHS KL2 TR001429NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIAAA NIH HHS F31 AA018238NIAAA NIH HHS P01 AA019072NIA NIH HHS P30 AG028740NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB016089NIMH NIH HHS K99 MH107719
Abstract
backgroundGamma-aminobutyric acid (GABA), the brain's principal inhibitory neurotransmitter, has been associated with perceptual and attentional functioning. Recent application of magnetic resonance spectroscopy (MRS) provides in vivo evidence for decreasing GABA concentrations during adulthood. It is unclear, however, how age-related decrements in cerebral GABA concentrations contribute to cognitive decline, or whether previously reported declines in cerebral GABA concentrations persist during healthy aging. We hypothesized that participants with higher GABA concentrations in the frontal cortex would exhibit superior cognitive function and that previously reported age-related decreases in cortical GABA concentrations continue into old age.
methodsWe measured GABA concentrations in frontal and posterior midline cerebral regions using a Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS)
resultsGreater frontal GABA concentrations were associated with superior cognitive performance. This relation remained significant after controlling for age, years of education, and brain atrophy. GABA concentrations in both frontal and posterior regions decreased as a function of age.
conclusionsThese novel findings from a large, healthy, older population indicate that cognitive function is sensitive to cerebral GABA concentrations in the frontal cortex, and GABA concentration in frontal and posterior regions continue to decline in later age. These effects suggest that proton MRS may provide a clinically useful method for the assessment of normal and abnormal age-related cognitive changes and the associated physiological contributors.
Indexed as
AgingCognitionGABAMEGA-PRESSMRSγ-Aminobutyric
Identifiers
What OpenQuestion holds
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Registered trials
NCT06284720ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.