Evidence map›Paper›PMID 28217742›Full record

ArticlemSphere

Piericidin A1 Blocks

Jessica M Morgan, Miles C Duncan, Kevin S Johnson, Andreas Diepold, Hanh Lam, Allison J Dupzyk, Lexi R Martin, Weng Ruh Wong, Judith P Armitage, Roger G Linington and 1 more

Open access · goldAbstract read
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Anti-infective compounds forSustainable microbiology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Inhibitory Activity ofThe plant pathology journal · 2020
    Article
  12. Article
  13. Natural Product Type III Secretion System Inhibitors.Antibiotics (Basel, Switzerland) · 2019
    Review
  14. Review
  15. Review
  16. Article
  17. Synthetic Cyclic Peptomers as Type III Secretion System Inhibitors.Antimicrobial agents and chemotherapy · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jessica M MorganDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA.
Miles C DuncanDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Kevin S JohnsonDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Andreas DiepoldDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Hanh LamDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA.
Allison J DupzykDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Lexi R MartinDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Weng Ruh WongDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA.
Judith P ArmitageDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4983-9731
Roger G LiningtonDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA.
Victoria AuerbuchDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
University of California, Santa Cruz · USUniversity of Oxford · GB

Funding

UNIVERSITY OF CALIFORNIA, SANTA CRUZ IMSD PROGRAMR25GM058903 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 1999 to 2019
$12.2M
UCSC Research Mentoring Internship Program: An Initiative to Increase Diversity and Inclusion in Genomics ResearchR25HG006836 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI BROOKS, ANGELA NORIE, RAMON, MARINA L · 2013 to 2025
$3.7M
Innate immunity-based screen for bacterial type III secretion system inhibitorsR01AI106930 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI STONE, VICTORIA AUERBUCH · 2014 to 2016
$1.2M
NCRR: UCSC Integrated Small Molecule Screening FacilityS10RR022455 · NCRR · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI LOKEY, R SCOTT · 2007 to 2007
$500k
NCRR NIH HHS S10 RR022455NHGRI NIH HHS R25 HG006836NIAID NIH HHS R01 AI106930NIGMS NIH HHS R25 GM058903Wellcome Trust
6 · The paper itself

Abstract

The type III secretion system (T3SS) is a bacterial virulence factor expressed by dozens of Gram-negative pathogens but largely absent from commensals. The T3SS is an attractive target for antimicrobial agents that may disarm pathogenic bacteria while leaving commensal populations intact. We previously identified piericidin A1 as an inhibitor of the Ysc T3SS in

Indexed as

piericidinT3SStype III secretion systemvirulence blockerYersinia

Identifiers

PMID28217742
PMCPMC5311113
OpenAlexW2588401112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.