Evidence map›Paper›PMID 28217698›Full record

ReviewAnnals of translational medicine2017

Questions and challenges associated with studying the microbiome of the urinary tract.

Yige Bao, Kait F Al, Ryan M Chanyi, Samantha Whiteside, Malcom Dewar, Hassan Razvi, Gregor Reid, Jeremy P Burton

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03987126 phase3completednot on this mapstarted 2021, after this paper: background citation

Use of Novel Human Milk Prebiotics to Improve the Quality of Life for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2021 to 2023Enrolled30ConditionsSpinal Cord Injuries, Neurogenic Bowel, Bladder DysfunctionArmsHuman Milk Oligosaccharides (HMO), Placebo
NCT04428190 early_phase1unknown statusnot on this mapstarted 2022, after this paper: background citation

Prebiotic Therapy to Improve Outcomes of Renal Transplant

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2022 to 2024Enrolled60ConditionsKidney Transplant, ComplicationsArmsHuman Milk Oligosaccharides (HMO), Placebo
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. The microbiota and renal cell carcinoma.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
  7. The Urinary Microbiome in Health and Disease: Relevance for Bladder Cancer.International journal of molecular sciences · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Impact of intestinal flora on calcium oxalate stones.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Bacteriophages of the lower urinary tract.Nature reviews. Urology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yige BaoDepartment of Surgery, Division of Urology, Western University, London, Canada;; Department of Microbiology & Immunology, Western University, London, Canada;; Canadian Centre for Human Microbiome and Probiotics, London, Canada.
Kait F AlDepartment of Surgery, Division of Urology, Western University, London, Canada;; Department of Microbiology & Immunology, Western University, London, Canada;; Canadian Centre for Human Microbiome and Probiotics, London, Canada.
Ryan M ChanyiDepartment of Surgery, Division of Urology, Western University, London, Canada;; Department of Microbiology & Immunology, Western University, London, Canada;; Canadian Centre for Human Microbiome and Probiotics, London, Canada.
Samantha WhitesideDepartment of Surgery, Division of Urology, Western University, London, Canada;; Department of Microbiology & Immunology, Western University, London, Canada;; Canadian Centre for Human Microbiome and Probiotics, London, Canada.
Malcom DewarDepartment of Surgery, Division of Urology, Western University, London, Canada.
Hassan RazviDepartment of Surgery, Division of Urology, Western University, London, Canada.
Gregor ReidDepartment of Surgery, Division of Urology, Western University, London, Canada;; Department of Microbiology & Immunology, Western University, London, Canada;; Canadian Centre for Human Microbiome and Probiotics, London, Canada.
Jeremy P BurtonDepartment of Surgery, Division of Urology, Western University, London, Canada;; Department of Microbiology & Immunology, Western University, London, Canada;; Canadian Centre for Human Microbiome and Probiotics, London, Canada.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urologists are typically faced with clinical situations for which the microbiome may have been a contributing factor. Clinicians have a good understanding regarding the role of bacteria related to issues such as antibiotic resistance; however, they generally have a limited grasp of how the microbiome may relate to urological issues. The largest part of the human microbiome is situated in the gastrointestinal tract, and though this is mostly separated from the urinary system, bacterial dissemination and metabolic output by this community is thought to have a significant influence on urological conditions. Sites within the urogenital system that were once considered "sterile" may regularly have bacterial populations present. The health implications potentially extend all the way to the kidneys. This could affect urinary tract infections, bladder cancer, urinary incontinence and related conditions including the formation of kidney stones. Given the sensitivity of the methodologies employed, and the large potential for contamination when working with low abundance microbiomes, meticulous care in the analyses of urological samples at various sites is required. This review highlights the opportunities for urinary microbiome investigations and our experience in working with these low abundance samples in the urinary tract.

Indexed as

low bacterial abundanceMicrobiomesample contamination

Identifiers

PMID28217698
PMCPMC5300849
OpenAlexW2572860403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.